The tamA gene of Aspergillus nidulans contains a putative zinc cluster motif which is not required for gene function.
AUTOR(ES)
Davis, M A
RESUMO
Expression of many nitrogen catabolic enzymes is controlled by nitrogen metabolite repression in Aspergillus nidulans. Although the phenotypes of tamA mutants have implicated this gene in nitrogen regulation, its function is unknown. We have cloned the tamA gene by complementation of a new tamA allele. The tamA sequence shares significant homology with the UGA35/DAL81/DURL gene of Saccharomyces cerevisiae. In vitro mutagenesis of sequences encoding a putative zinc cluster DNA binding domain indicated that this motif is not required for in vivo TamA function.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=178106Documentos Relacionados
- Baculovirus gene ME53, which contains a putative zinc finger motif, is one of the major early-transcribed genes.
- Calcium Binding Is Required for Calmodulin Function in Aspergillus nidulans
- stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans.
- Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin.
- The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function.