The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

AUTOR(ES)

Amzel, L. M.

RESUMO

IgG New binds ligands such as orceine, menadione, and uridine with a low affinity (K0 about 1 × 103 liter/mol) and a γ-hydroxy derivative of vitamin K1 with a higher affinity (K0 = 1.7 × 105 liter/mol). Binding studies indicate that both the 2-methylnaphthoquinone rings and the phytyl tail of the vitamin K1 hapten contribute to the total binding energy.

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