Theoretical methods for study of kinetics of models of the mitochondrial respiratory chain.

AUTOR(ES)

Hill, T L

RESUMO

In earlier work, Hill and Chance obtained exact steady-state kinetic properties for partial models of the mitochondrial respiratory chain with two isopotential pools and one four-state "site enzyme" between the two pools. That work is extended here to full models of the respiratory chain with four isopotential pools and three four-state site enzymes between pairs of pools. Because of the complexity of the model, exact calculations are no longer possible. Instead, we show, by means of some examples, the feasibility of using Monte Carlo calculations on all cases and numerical solution of thousands of kinetic differential equations in many cases.

Documentos Relacionados

• Flavoproteins of the mitochondrial respiratory chain.
• The general mitochondrial processing peptidase from potato is an integral part of cytochrome c reductase of the respiratory chain.
• Impaired mitochondrial beta-oxidation in a patient with an abnormality of the respiratory chain. Studies in skeletal muscle mitochondria.
• Energetic efficiency of Escherichia coli: effects of mutations in components of the aerobic respiratory chain.
• Definition of cytochrome c binding domains by chemical modification: Kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain*