Therapy of Staphylococcal Infections in Monkeys. IV. Further Comparison of Triacetyloleandomycin and Erythromycins
AUTOR(ES)
Saslaw, Samuel
RESUMO
Intravenous inoculation of a penicillin-resistant, phage type 80/81 staphylococcus caused lethal infection in 8 of 15 untreated monkeys. Daily intragastric administration of 50 mg/kg of triacetyloleandomycin, erythromycin estolate, and erythromycin ethylsuccinate was followed by mortalities of 0 of 16, 3 of 16, and 3 of 10, respectively. At dose levels of 25 and 12.5 mg/kg, none of 7 and 4 of 7 receiving triacetyloleandomycin and erythromycin estolate, respectively, died, as compared to 3 of 4 deaths in controls. In vitro sensitivity data and serum antibacterial levels would suggest that triacetyloleandomycin would be the least effective therapeutically. However, this prediction was not fulfilled in these studies of experimental infections in monkeys wherein triacetyloleandomycin was a very effective antimicrobial agent.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=378196Documentos Relacionados
- Therapy of Staphylococcal Infections in Monkeys: VII. Comparison of Cyclacillin and Nafcillin
- Therapy of Staphylococcal Infections in Monkeys: VI. Comparison of Clindamycin, Erythromycin, and Methicillin
- Experimental Infection of the Skin in the Hamster Simulating Human Impetigo IV. Cellular Responses after Streptococcal and Staphylococcal Infections
- Gametophytic Inheritance in Sphaerocarpos. IV. Further Studies of Tuftedness and Polyclady
- Chemotherapy of experimental streptococcal endocarditis. IV. Further observations on prophylaxis.
