Three monoclonal antibodies against measles virus F protein cross-react with cellular stress proteins.
AUTOR(ES)
Sheshberadaran, H
RESUMO
In a group of 11 monoclonal antibodies specifically reacting with the measles virus fusion protein, three antibodies also immunoprecipitated other proteins, in particular a 79,000-molecular-weight protein from virus-infected cells. The cross-reacting 79,000-molecular-weight protein was shown to be a virus-induced host stress protein. This protein could be induced by (i) different paramyxoviruses, (ii) heat shock of uninfected HeLa cells, and (iii) 2-deoxyglucose, tunicamycin, or L-canavanine treatment of different mammalian cell lines. Immunofluorescence of stressed HeLa cells localized the cross-reacting host protein(s) mainly in the cytoplasm. The significance of these results in relation to autoimmunity is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254628Documentos Relacionados
- Monoclonal antibodies to Staphylococcus aureus laminin-binding proteins cross-react with mammalian cells.
- Maize mesocotyl plasmodesmata proteins cross-react with connexin gap junction protein antibodies.
- ANTIBODIES TO HAPTEN-CONJUGATED PROTEINS WHICH CROSS-REACT WITH RNA
- Monoclonal antibodies to Coxiella burnetii that cross-react with strain Nine Mile.
- Monoclonal antibodies against enterotoxigenic Escherichia coli colonization factor antigen I (CFA/I) that cross-react immunologically with heterologous CFAs.
