Thymidine-Dependent Small-Colony Variants of Staphylococcus aureus Exhibit Gross Morphological and Ultrastructural Changes Consistent with Impaired Cell Separation

AUTOR(ES)

Kahl, Barbara C.

FONTE

American Society for Microbiology

RESUMO

Thymidine-dependent small-colony variants (SCV) of Staphylococcus aureus exhibited unusual colony morphology with “fried-egg” or pinpoint white colonies on agar plates and pleomorphic cocci as determined by Gram staining. Electron microscopy revealed enlarged cocci with incomplete or multiple cross walls consistent with impaired cell separation. Fried-egg SCV phenotypes could be reversed by thymidine supplementation.

Documentos Relacionados

• Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis.
• Evaluation of Different Methods To Detect Methicillin Resistance in Small-Colony Variants of Staphylococcus aureus
• Gentamicin Uptake in Wild-Type and Aminoglycoside-Resistant Small-Colony Mutants of Staphylococcus aureus
• Small-Colony Mutants of Staphylococcus aureus Allow Selection of Gyrase-Mediated Resistance to Dual-Target Fluoroquinolones
• A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly.