Tip cell-derived RTK signaling initiates cell movements in the Drosophila stomatogastric nervous system anlage
AUTOR(ES)
González-Gaitán, Marcos
FONTE
Oxford University Press
RESUMO
The stomatogastric nervous system (SNS) of Drosophila is a simply organized neural circuitry that innervates the anterior enteric system. Unlike the central and the peripheral nervous systems, the SNS derives from a compact epithelial anlage in which three invagination centers, each giving rise to an invagination fold headed by a tip cell, are generated. Tip cell selection involves lateral inhibition, a process in which Wingless (Wg) activity adjusts the range of Notch signaling. Here we show that RTK signaling mediated by the Drosophila homolog of the epidermal growth factor receptor, DER, plays a key role in two consecutive steps during early SNS development. Like Wg, DER signaling participates in adjusting the range of Notch-dependent lateral inhibition during tip cell selection. Subsequently, tip cells secrete the DER ligand Spitz and trigger local RTK signaling, which initiates morphogenetic movements resulting in the tip cell-directed invaginations within the SNS anlage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1083741Documentos Relacionados
- JC Virus Induces Nonapoptotic Cell Death of Human Central Nervous System Progenitor Cell-Derived Astrocytes
- Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver.
- Primate origin of the cell-derived sequences of simian sarcoma virus.
- Factors involved in regulation of the RT7 promoter in a male germ cell-derived in vitro transcription system.
- Proposal for Naming Host Cell-Derived Inserts in Retrovirus Genomes †