Topical steroid, cyclosporin A, and the outcome of rat corneal allografts.
AUTOR(ES)
Williams, K A
RESUMO
The effects of a combination of topical corticosteroid and cyclosporin A on corneal graft survival were tested in a model of penetrating keratoplasty in the inbred rat. Topical medications were applied four times daily to the graft for 28 days postgraft. Neither topical steroid (1% prednisolone acetate) nor topical cyclosporin (1% in chremophor EL/ethanol) was able to modify the overall incidence of rejection, though all steroid-containing medications delayed the onset of rejection significantly. The combined formulation of steroid plus cyclosporin A caused a reduction in the incidence of rejection which did not reach statistical significance and which did not eliminate the response in all animals. The chremophor/ethanol vehicle was reasonably well tolerated but did cause some periocular dermatitis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1041128Documentos Relacionados
- Morphological differentiation between rejection and cyclosporin nephrotoxicity in renal allografts.
- Early and persistent induction of monocyte chemoattractant protein 1 in rat cardiac allografts.
- Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts.
- Preparation of venous allografts. A comparison of techniques.
- Psoriasis, cyclosporin A, and AIDS.