Toward an analogue of alcoholism in mice: scale factors in the model.

AUTOR(ES)

Dole, V P

RESUMO

Mice of the C57BL strain, given continuous access to 10% alcohol and plain water, with unlimited food and no stress, frequently drink enough alcohol to produce intoxicating levels in the blood. Nevertheless, this behavior does not appear to replicate the essential features of human alcoholism since the drinking lacks serious toxic effects and the intoxication occurs only as transient episodes in association with homeostatic consumption of fluid and food. It is suggested that continuous monitoring of intake and estimation of the concentration of alcohol in blood, which are now technically feasible, will permit distinction between alcoholic-type drinking and a simple licking for the flavor of alcohol in beverage concentration.

Documentos Relacionados

• Toward an analogue of alcoholism in mice: criteria for recognition of pharmacologically motivated drinking.
• Toward an analogue of alcoholism in mice: analysis of nongenetic variance in consumption of alcohol.
• The Canon Group's effort: working toward a merged model.
• Public attitudes toward alcoholism as an illness.
• Genital herpesvirus hominis infection in mice. I. Development of an experimental model.