Toxicity of organic acids for repair-deficient strains of Escherichia coli.
AUTOR(ES)
Sinha, R P
RESUMO
The wild-type strain and four DNA repair-deficient strains (uvrA6, uvrB5, recA56, and polA1) of Escherichia coli K-12 were treated with acetic acid, lactic acid, and p-aminobenzoic acid at pH 3.5 during their stationary phase of growth. All three acids were highly toxic to the polymerase-deficient strain. The greater sensitivity of the strain carrying the polA1 gene than its isogenic pol+ derivatives suggested that damage caused by acidity requires polA+ gene products for repair.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=239074Documentos Relacionados
- Toxicity of Irradiated Medium for Repair-Deficient Strains of Escherichia coli
- In vitro host cell reactivation of alkylated bacteriophage T7 deoxyribonucleic acid by repair-deficient strains of Escherichia coli.
- Meiotic Recombination and Sporulation in Repair-Deficient Strains of Yeast
- A Defect in the Acetyl Coenzyme A↔Acetate Pathway Poisons Recombinational Repair-Deficient Mutants of Escherichia coli
- Altered spectra of hypermutation in DNA repair-deficient mice.
