Transcription-Induced Cytosine-to-Thymine Mutations Are Not Dependent on Sequence Context of the Target Cytosine

AUTOR(ES)

Beletskii, Anton

FONTE

American Society for Microbiology

RESUMO

We showed previously that transcription of a plasmid-borne kan allele increases C-to-T mutations in the nontranscribed strand. Using two new plasmid-borne kan alleles, one cmp allele, and a chromosomal kan allele, we found in this study that transcription-induced mutations are not limited to specific genes, alleles, or locations and are likely to be a general property of transcript elongation in Escherichia coli.

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