Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene.
AUTOR(ES)
Nerenberg, M I
RESUMO
Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240995Documentos Relacionados
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