Translation of capped viral mRNAs in poliovirus-infected HeLa cells.
AUTOR(ES)
Alonso, M A
RESUMO
HeLa cells doubly infected with Semliki Forest virus (SFV) and poliovirus synthesize either more poliovirus proteins or more SFV late proteins depending on the time of super-infection with poliovirus. Under some conditions, the infected cells translate uncapped poliovirus mRNA and capped 26S mRNA from SFV simultaneously, even though host protein synthesis has been shut down. Vesicular stomatitis virus (VSV) protein synthesis is depressed drastically when VSV-infected cells are super-infected with poliovirus. In cells doubly infected with VSV and encephalomyocarditis (EMC) virus or with VSV and SFV, dominance of one of the viruses depends on the time of addition of the challenge virus. The influence of external conditions on the relative translation of capped or uncapped viral mRNA in doubly infected cells has also been analysed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=553135Documentos Relacionados
- Virus-specified protease in poliovirus-infected HeLa cells.
- Guanidine-sensitive Na+ accumulation by poliovirus-infected HeLa cells.
- Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.
- mRNAs containing the unstructured 5' leader sequence of alfalfa mosaic virus RNA 4 translate inefficiently in lysates from poliovirus-infected HeLa cells.
- Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.
