Translocation of proteins across the mitochondrial inner membrane, but not into the outer membrane, requires nucleoside triphosphates in the matrix.

AUTOR(ES)

Hwang, S T

RESUMO

Work in several laboratories has established that import of proteins across the mitochondrial inner membrane requires an electrochemical potential across that membrane and cleavage of nucleoside triphosphate. We now show that nucleoside triphosphate must be present inside the inner membrane. In contrast, the potential-independent insertion of porin into the outer membrane requires ATP only outside the inner membrane.

Documentos Relacionados

• Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane
• Import of an incompletely folded precursor protein into isolated mitochondria requires an energized inner membrane, but no added ATP.
• J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix
• Sequential action of mitochondrial chaperones in protein import into the matrix.
• The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum.