Transport of infectious reovirus into bile: class II major histocompatibility antigen-bearing cells determine reovirus transport.
AUTOR(ES)
Rubin, D H
RESUMO
We have previously demonstrated that mammalian reovirus type 1 enters the bile and gut lumen after systemic administration. In the present study, we showed that Kupffer cell uptake is essential for the transport of reovirus into the bile. Furthermore, class II major histocompatibility antigen (I-A)-bearing cells are a major determinant for the transit of reovirus from the hepatic environment, as well as from the intestine, during the course of systemic infection. These findings may provide an approach to the control of viral pathogens that cause systemic disease by selective utilization or modification of I-A-bearing cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=255901Documentos Relacionados
- Identification of the mouse cytomegalovirus genomic region affecting major histocompatibility complex class I molecule transport.
- Characterization of naturally processed antigen bound to major histocompatibility complex class II molecules.
- Regulation of major histocompatibility complex class II gene expression in trophoblast cells
- Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity
- Protection against Ascending Infection of the Genital Tract by Chlamydia trachomatis Is Associated with Recruitment of Major Histocompatibility Complex Class II Antigen-Presenting Cells into Uterine Tissue