Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis
AUTOR(ES)
Lewis, L. A.
FONTE
American Society for Microbiology
RESUMO
The meningococcal hemA gene was cloned and used to construct a porphyrin biosynthesis mutant. An analysis of the hemA mutant indicated that meningococci can transport intact porphyrin from heme (Hm), hemoglobin (Hb), and Hb-haptoglobin (Hp). By constructing a HemA− HpuAB− double mutant, we demonstrated that HpuAB is required for the transport of porphyrin from Hb and Hb-Hp.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=107682Documentos Relacionados
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