Triterpenoids from Azorella trifurcata (Gaertn.) Pers and their effect against the enzyme acetylcholinesterase
AUTOR(ES)
Areche, Carlos, Cejas, Patricia, Thomas, Pablo, San-Martín, Aurelio, Astudillo, Luis, Gutiérrez, Margarita, Loyola, Luis A
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2009
RESUMO
The inhibition of the enzyme acetylcholinesterase is considered as a strategy for the treatment of Alzheimer's disease, senile dementia, ataxia, and myasthenia gravis. Three lanostane- and two cycloartane-type triterpenes, together with two mulinane-type diterpenes were isolated from petroleum ether extract of the whole shrub of Azorella trifurcata (Gaertn.) Pers. Their effect on the enzyme acetylcholinesterase was assessed as well. In addition, this is the first report of these triterpenes in the genus Azorella.
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