Tubular Mechanism for the Spontaneous Hypercalciuria in Laboratory Rat

AUTOR(ES)

Lau, Kai

RESUMO

Recently it has been observed that Ca excretion in laboratory rats does not follow a Gaussian distribution, with ∼10% of them excreting Ca at a rate of 2 SD above the group mean. This phenomenon has been described as spontaneous hypercalciuria (SH). Our studies were designed to define its mechanism. 48 Wistar rats were subjected to metabolic studies to identify SH, prospectively defined as Ca excretion 2 SD above the group mean during 7 d of dietary Ca deprivation (≤0.03% by analysis), in the absence of hypercalcemia, PO4 depletion, or exaggerated natriuresis.

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