Ultraviolet irradiation inhibits encapsidation of simian virus 40 chromatin.
AUTOR(ES)
Roman, A
RESUMO
During normal maturation and majority of pulse-labeled simian virus 40 DNA progresses from chromatin to previrions and virions within 5 h. UV light inhibits this progression. In heavily irradiated cultures (108 J m-2) most of the simian virus 40 DNA synthesized immediately before irradiation remains as chromatin for at least 5 h. This inhibition of maturation seems to be a result of the inhibition of protein synthesis. The data suggest that the pool of proteins required for maturation is sufficient to convert one-third of the simian virus 40 DNA molecules labeled in a 10-min pulse (at 33 h postinfection) from chromatin to previrions and virions and is exhausted within 1 h.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=256684Documentos Relacionados
- Specific association of simian virus 40 tumor antigen with simian virus 40 chromatin.
- In vitro formation of multimeric DNA structures mediated by purified simian virus 40 chromatin.
- Deletion mutants which affect the nuclease-sensitive site in simian virus 40 chromatin.
- Spliced and unspliced virus specific RNA sequences are associated with purified simian virus 40 chromatin.
- Role of specific simian virus 40 sequences in the nuclease-sensitive structure in viral chromatin.
