Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe.
AUTOR(ES)
Minet, M
RESUMO
A temperature-sensitive Schizosaccharomyces pombe mutant, cdc16-116, has been isolated which undergoes uncontrolled septation during its cell division cycle. The mutant accumulates two types of cells after 3 h of growth at the restrictive temperature: (i) type I cells (85% of the population), which complete nuclear division and then form up to five septa between the divided nuclei; and (ii) type II cells (15% of the population), which form an asymmetrically situated septum in the absence of any nuclear division. cdc16-116 is a monogenic recessive mutation unlinked to any previously known cdc gene of S. pombe. It is not affected in a previously reported control by which septation is dependent upon completion of nuclear division. We propose the cdc16-116 is unable to complete septum formation and proceed to cell separation and is also defective in a control which prevents the manufacture of more than one septum in each cell cycle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=218468Documentos Relacionados
- Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe.
- Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.
- Analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe.
- Mammalian promoter element function in the fission yeast Schizosaccharomyces pombe.
- Construction of functional artificial minichromosomes in the fission yeast Schizosaccharomyces pombe.