Urinary cyclic adenosine monophosphate in young adults and elderly subjects.
AUTOR(ES)
Gennari, C
RESUMO
The 24-hour urinary excretion of cyclic 3',5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between cAMP excretion and age demonstrated a progressive decrease from the age of 70 to the tenth decade. Many different factors could account for the reduced urinary cAMP excretion in elderly subjects: a decline in the reactivity of the adenyl cyclase-cAMP system related to physiological ageing; reduced physical activity; a reduction in the glomerular filtration rate or decreased production of cAMP by tubular cells in the senile kidney.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=475949Documentos Relacionados
- Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects.
- Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects.
- Intraoperative urinary cyclic adenosine monophosphate as a guide to successful reoperative parathyroidectomy.
- Cyclic adenosine monophosphate, CA++, and membranes.
- Pharmacokinetics of moxalactam in elderly subjects.