Use of CB hamsters in the study of Treponema pertenue.
AUTOR(ES)
Schell, R F
RESUMO
The CB/Ss LAK strain of inbred hamster was used as a model for studies of infection with Treponema pertenue and of acquired resistance to it. When infected, this strain developed cutaneous lesions which lasted for six to seven months, even in the presence of peak titres of antitreponemal antibody. The rate of appearance and resolution of these lesions varied with the size of the inoculum. The infected hamsters' inguinal lymph nodes increased significantly in weight and teemed with treponemes for several weeks. Animals infected for eight or 10 weeks obtained quick resolution of their lesions by treatment with penicillin and were thereafter resistant to reinfection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1045670Documentos Relacionados
- Ability of enriched immune T cells to confer resistance in hamsters to infection with Treponema pertenue.
- Molecular basis of immunological cross-reactivity between Treponema pallidum and Treponema pertenue.
- Comparison of major protein antigens and protein profiles of Treponema pallidum and Treponema pertenue.
- Inability of immune cells treated with anti-thymocyte serum to confer on hamsters resistance to cutaneous infection with Treponema pertenue.
- Mitogenic responses of hamsters infected with Treponema pertenue Lack of correlation with passive transfer of resistance.