Vaccination with Attenuated Simian Immunodeficiency Virus by DNA Inoculation

AUTOR(ES)

Kent, Stephen J.

FONTE

American Society for Microbiology

RESUMO

Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIVmac239) DNA or SIVmac239 DNA containing a single deletion in the 3′ nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIVmac239 DNA containing identical deletions in both the 5′ LTR and 3′ nef/LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIVmac251 challenge.

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