Vaccine Efficacy of a Lysine Auxotroph of Mycobacterium tuberculosis
AUTOR(ES)
Pavelka, Martin S.
FONTE
American Society for Microbiology
RESUMO
The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=161997Documentos Relacionados
- Persistence and Protective Efficacy of a Mycobacterium tuberculosis Auxotroph Vaccine
- Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis
- Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection
- Attenuation of and Protection Induced by a Leucine Auxotroph of Mycobacterium tuberculosis
- Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs
