Virulence-related protein synthesis in Naegleria fowleri.
AUTOR(ES)
Hu, W N
RESUMO
Protein synthesis patterns of the low-virulence Naegleria fowleri LEE strain from axenic culture, the same strain after mouse brain passage to increase virulence, and the same strain after growth on bacteria were studied. Comparisons of accumulated proteins, in vivo-synthesized proteins, and in vitro-synthesized proteins translated from poly(A)+ mRNA were made. Differences between amoebae from the different treatments were noted. After 6 months in axenic culture, pathogenic protein synthesis patterns were lost and there was a decrease in virulence. Therefore, the increase in virulence is correlated with numerous specific changes in protein synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=259031Documentos Relacionados
- Cloning and characterization of transcripts showing virulence-related gene expression in Naegleria fowleri.
- Effect of clotrimazole on Naegleria fowleri.
- Clinical significance of virulence-related assay of Yersinia species.
- Biological factors affecting enflagellation of Naegleria fowleri.
- A multicomponent hemolytic system in the pathogenic amoeba Naegleria fowleri.