Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
AUTOR(ES)
Celikoglu, Emine, Aslanturk, Ayse, Kalender, Yusuf
FONTE
Braz. arch. biol. technol.
DATA DE PUBLICAÇÃO
2015-08
RESUMO
The aim of the present study was to elucidate the possible protective role of vitamin E and / or sodium selenite on mercuric chloride-induced oxidative stress and histopathological changes in the lung tissue of the rats. Adult male albino Wistar rats were exposed to mercuric chloride (1.0 mg/kg day) for four weeks. Treatment with mercuric chloride led to oxidative stress by enhancing MDA level and also decreasing superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione S transferaz (GST) activities. However, mercuric chloride exposure resulted in histopathological changes in the lung tissue in the rats. MDA level and SOD, CAT GPx and GST activities and histopathological changes modulated in concomitantly supplementation of vitamin E (100 mg/kg day) and /or sodium selenite (0.25 mg/kg day) to mercuric chloride-treated groups.
Documentos Relacionados
- Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats
- Cesium chloride-induced torsades de pointes
- Erythrocyte Hemolysis and Hemoglobin Oxidation Promote Ferric Chloride-induced Vascular Injury*S⃞
- Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite
- RELATIONSHIP BETWEEN VITAMIN B12 OXIDATION PRODUCT AND SODIUM CHLORIDE TOXICITY FOR LACTOBACILLI