Weak serum and intestinal antibody responses to Vibrio cholerae soluble hemagglutinin in cholera patients.
AUTOR(ES)
Svennerholm, A M
RESUMO
A soluble hemagglutinin/protease from Vibrio cholerae has been suggested to be a putative virulence factor and protective antigen. However, clinical cholera infection gave rise to detectable serum antibody responses to soluble hemagglutinin in only 2 of 10 Bangladeshi patients or 1 of 17 cholera-infected North American volunteers. A gut mucosal immunoglobulin A antibody response to soluble hemagglutinin was seen in 4 of 8 Bangladeshi patients, but in 0 of 10 North American volunteers. These responses were much weaker than those to cholera toxin or lipopolysaccharide.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=263371Documentos Relacionados
- Experimental Cholera in Chinchillas: the Immune Response in Serum and Intestinal Secretions to Vibrio cholerae and Cholera Toxin
- Purification and characterization of the soluble hemagglutinin (cholera lectin)( produced by Vibrio cholerae.
- Vibrio cholerae hemagglutinin/protease nicks cholera enterotoxin.
- Intestinal myoelectric activity in response to live Vibrio cholerae and cholera enterotoxin.
- Immune response to the mannose-sensitive hemagglutinin in patients with cholera due to Vibrio cholerae O1 and O0139.