What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis

AUTOR(ES)

FONTE

RESUMO

The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Predominantly, T cells and monocytes are found in inflammatory infiltrates in patients with Wegener's granulomatosis (WG). The production of ANCA appears to be T-cell-dependent. T lymphocytes from the peripheral blood of patients with ANCA-associated vasculitis have been shown to proliferate in response to proteinase 3 (PR3). These and other findings outlined in this review indicate T-cell involvement, although further studies are still needed to elucidate the exact contribution of T cells to the pathogenesis of systemic vasculitis.

Documentos Relacionados

• What you should know about PR3-ANCA: An introduction
• What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
• What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA
• What the radiologist should know about the role of interventional radiology in urology
• What should the citizen know about science?