Aziridine
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Síntese de β-Calcogenoaminas quirais via abertura regiosseletiva de Aziridinas em Líquidos Iônicos. / Synthesis of β-chalcogen amine derivatives from regioselective aziridine ring-opening in ionic liquids.
O presente trabalho tem por objetivo a síntese de β-Calcogenoaminas quirais derivadas de L-aminoácidos empregando uma metodologia simples, com apelo ambiental e com bons rendimentos. O protocolo utilizado envolveu a reação de abertura de aziridinas Nprotegidas com grupamentos Boc e Tosil (2a-g) utilizando zinco em pó, 10 L de HCl (1M), disseleneto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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2. Metodologia AGOA: a modelagem de clusters de hidratação no complexo aziridina···ácido fluorídrico
We present a theoretical study of solvent effect on C2H5N···HF hydrogen-bonded complex through the application of the AGOA methodology. By using the TIP4P model to orientate the configuration of water molecules, the hydration clusters generated by AGOA were obtained through the analysis of the molecular electrostatic potential (MEP) of solute (C2H5N···
Química Nova. Publicado em: 2009
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3. Recentes avanços na preparação de aziridinas. Aplicações sintéticas e implicações mecanísticas
This article surveys a selection of the most recent advances in aziridine synthesis. Novel synthetic methods and new insights into existing methodologies for the selective construction of the title compounds reported in the past decade are discussed in terms of synthetic applicability and environmentally benign conditions. Mechanisms involving stereoselectiv
Química Nova. Publicado em: 2007-02
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4. Investigation of a New Synthetic Route to (R)-Baclofen / Estudo de uma nova rota sintética para o fármaco (R)-baclofen
In this work, the feasibility of a new synthetic route to Baclofen was investigated. The starting material, a cis-aziridine, was prepared by ring closure of (2S,3R)-(4-clorophenyl)- serine, under phase transfer conditions (PTC). As for the preparation of the required ß- hydroxy-α-aminoacid, two alternative synthetic strategies were investigated. (i) th
Publicado em: 2007
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5. Enantioselective synthesis of aziridines using asymmetric transfer hydrogenation as a precursor for chiral derivatives used as bonding agent for rocket solid propellants
A rapid, expedient and enantioselective method for the synthesis of beta-hydroxy amines and monosubstituted aziridines in up to 99% e.e., via asymmetric transfer hydrogenation of a-amino ketones and cyclisation through treatment with tosyl chloride and base, is described. (1R,2R)-N-(para-toluenesulfonyl)-1,2-ethylenediamine with formic acid has been utilised
Química Nova. Publicado em: 2002-11
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6. Reduction of the toxicity and mutagenicity of aziridine in mammalian cells harboring the Escherichia coli fpg gene.
Aziridine (ethyleneimine) reacts with DNA in vitro, mainly at the N7 position of guanine and N3 of adenine, then imidazole ring opening of the modified guanine results in formation of formamidopyrimidine (FaPy) residues. The Escherichia coli fpg gene encodes a DNA glycosylase that removes FaPy residues from DNA. To determine whether aziridine produces FaPy l
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7. Inhibitory Effects of Mitomycin-Related Compounds Lacking the C1-C2 Aziridine Ring
Three chemical derivatives of mitomycin C cause loss of viability, inhibition of deoxyribonucleic acid synthesis, and inhibition of cell division in bacteria. Each of these drugs lacks the C1-C2 aziridine ring previously postulated to be essential for the bactericidal effect of mitomycin C.
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8. Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine.
The class I major histocompatibility complex (MHC) glycoprotein HLA-B27 binds short peptides containing arginine at peptide position 2 (P2). The HLA-B27/peptide complex is recognized by T cells both as part of the development of the repertoire of T cells in the cellular immune system and during activation of cytotoxic T cells. Based on the three-dimensional
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9. Viral capsid mobility: A dynamic conduit for inactivation
Mass spectrometry and fluorescent probes have provided direct evidence that alkylating agents permeate the protein capsid of naked viruses and chemically inactivate the nucleic acid. N-acetyl-aziridine and a fluorescent alkylating agent, dansyl sulfonate aziridine, inactivated three different viruses, flock house virus, human rhinovirus-14, and foot and
The National Academy of Sciences.
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10. Degradation kinetics and mechanism of RH1, a new anti-tumor agent: A technical note
The degradation of RH1 in aqueous solution is found to be both acid and base catalyzed. The maximum stability is obtained in neutral pH but still degrades by 10% (t90) after just 1 week. The stability profile at pH 5 was done, and 4 major degradation products were observed in acid solutions. LC-MS was performed and the molecular weights determined, from whic
Springer-Verlag.
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11. Nuclear estrogen receptor molecular heterogeneity in the mouse uterus.
Holomeric estrogen receptor (ER) prepared from ovariectomized mouse uteri displays heterogeneous electrophoretic mobility when analyzed by NaDodSO4/PAGE. ER derived from nuclei (ERn) appears as a closely spaced doublet having apparent molecular masses of 66.4 and 65 kDa, while ER from the cytosolic compartment (ERc) has a single band of 65 kDa. Both partiall
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12. Immunodetection of estrogen receptor in epithelial and stromal tissues of neonatal mouse uterus.
The tissue distribution and levels of estrogen receptor in neonatal mouse uterine tissue were determined in epithelial and stromal fractions separated by mild enzymatic treatment. Proteins of the isolated fractions were separated by gel electrophoresis and receptor was detected on immunoblots with monoclonal antibody H-222. Estrogen receptor protein was dete