Benzimidazole Derivatives
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. A New Synthetic Route and Comprehensive Topological Study of a Benzimidazole Derivative
Benzimidazole and its derivatives are molecules that have diverse biological properties, therefore we synthesized and studied a new benzimidazole to understand their physical/chemical properties. The compound was obtained through a new synthetic route, using graphite oxide, in the absence of solvent, with crystalline packaging supported by C-H…N and C-H…
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes
Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs. Benzimidazole 2-carbamates, a class of well-known broad-spectrum anthelmintics, have been shown to inhibit the in vitro growth of many protozoa
Mem. Inst. Oswaldo Cruz. Publicado em: 09/09/2014
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3. Desenhos de estruturas químicas correlacionam-se com propriedades biológicas: MIA-QSAR
Descriptors in multivariate image analysis applied to quantitative structure-activity relationship (MIA-QSAR) are pixels of bidimensional images of chemical structures (drawings), which were used to model the trichomonicidal activities of a series of benzimidazole derivatives. The MIA-QSAR model showed good predictive ability, with r², q² and r val. ext.²
Química Nova. Publicado em: 2012
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4. Estudo das propriedades térmicas de filmes poliméricos compostos de speek, derivados de benzoimidazol e ácido fosfotúngstico / Thermal Properties of Speek-based Polymeric Films Containing Benzimidazole Derivatives and Fosfotungstic Acid
Filmes poliméricos foram desenvolvidos a partir de poli (éter éter cetona) sulfonado (SPEEK), derivados do benzoimidazol e ácido fosfotúngstico (HPW). Neste trabalho foi realizado um estudo utilizando a análise termogravimétrica com o objetivo de avaliar a estabilidade térmica e determinar as condições de temperatura a que podem ser submetidos os f
Publicado em: 2010
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5. Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues
A síntese de uma série de arilpiperazinas ligadas à estrutura 2-(piridina-3-il)-1H-benzo[d]imidazol, através de um linker alquílico é relatada. Os novos derivados 1-(2-(4-arilpiperazina-1-il)alquil)-2-(piridina-3-il)-1H-benzimidazol são estruturalmente relacionados à droga anti-HIV-1 Delavirdina e pertencem à família bis(heteroaril)piperazinas (BHA
Journal of the Brazilian Chemical Society. Publicado em: 2010
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6. Ruthenium and iron complexes with benzotriazole and benzimidazole derivatives as simple models for proton-coupled electron transfer systems
Complexos de ferro e rutênio do tipo [M-LH]n (onde M = RuII,III(NH3)5(2+,3+), RuII,III(edta)2-,- [edta = etilenodinitrilotetraacetato], ou FeII,III(CN)5(3-,2-) e LH = benzotriazol ou benzoimidazol) foram preparados e caracterizados em solução aquosa através de métodos eletroquímicos e espectroeletroquímicos. Neste trabalho, maior ênfase foi direciona
Journal of the Brazilian Chemical Society. Publicado em: 2001-04
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7. Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence.
Benzimidazoles have been widely used since the 1960s as anthelmintic agents in veterinary and human medicine and as antifungal agents in agriculture. More recently, selected benzimidazole derivatives were shown to be active in vitro against two protozoan parasites, Trichomonas vaginalis and Giardia lamblia, and clinical studies with AIDS patients have sugges
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8. Conformation of nucleosides: circular dichroism study on the syn-anti conformational equilibrium of 2-substituted benzimidazole nucleosides.
The solution conformations of 2-substituted derivatives of 1-(beta-D-ribofuranosyl)benzimidazole have been determined by circular dichroism spectroscopy in aqueous solutions. It is shown that analogs with methyl, amino, or methylamino substituents at position 2 of the benzimidazole ring (position 8 of the purine ring) have predominantly anti conformations, w
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9. In vitro susceptibilities of the AIDS-associated microsporidian Encephalitozoon intestinalis to albendazole, its sulfoxide metabolite, and 12 additional benzimidazole derivatives.
Recent reports have described the successful treatment of Encephalitozoon intestinalis infection in AIDS patients with albendazole. However, this compound is rapidly metabolized in vivo to albendazole sulfoxide, and furthermore it is only 1 of about 15 commercially developed benzimidazole derivatives. To compare the activities of albendazole, albendazole sul
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10. Antibacterial and antifungal activities of benzimidazole and benzoxazole derivatives.
The in vitro antibacterial and antifungal activities of six benzimidazole and benzoxazole derivatives were tested against standard strains and 59 clinical isolates. Of the six compounds, only compounds II and III (both benzoxazoles) were active, whereas the rest were devoid of any activity. Considerable growth inhibition of all of the standard strains, inclu
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11. Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii.
Nine antimicrotubule benzimidazole derivatives tested in a Pneumocystis carinii culture system with human embryonic lung fibroblast monolayers inhibited organism proliferation. The concentrations of drugs inhibitory in culture ranged from 10 to 0.1 micrograms/ml, with thiabendazole being the least effective (10 micrograms/ml) and parbendazole being the most
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12. Substitution of Co alpha-(5-hydroxybenzimidazolyl)cobamide (factor III) by vitamin B12 in Methanobacterium thermoautotrophicum.
Methanobacterium thermoautotrophicum grown on mineral medium contains 120 nmol of Co alpha-(5-hydroxybenzimidazolyl)cobamides (derivatives of factor III) per g of dry cell mass as the sole cobamide. The bacterium assimilated several corrinoids and benzimidazole bases during autotrophic growth. The corrinoids were converted into factor III; however, after thr