Benzophenones
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding ant
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Synthesis of 1,2,3-Triazole Benzophenone Derivatives and Evaluation of in vitro Sun Protection, Antioxidant Properties, and Antiproliferative Activity on HT-144 Melanoma Cells
Benzophenones display several biological activities, including antioxidant, anticancer, and photoprotective. Furthermore, antioxidants can minimize both ultraviolet absorption and tumor development. In the present investigation, a series of twenty-six 1,2,3-triazole-benzophenone derivatives were synthesized and had their antioxidant, anticancer, and photopro
J. Braz. Chem. Soc.. Publicado em: 2021-03
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3. SÍNTESE E AVALIAÇÃO DAS ATIVIDADES FOTOPROTETORA, CITOTÓXICA E ANTIVIRAL CONTRA O ZIKA VÍRUS DE DERIVADOS TRIAZÓLICOS DA BENZOFENONA
The benzophenones are synthetic and natural compounds presenting a variety of activities, including photoprotective, cytotoxic and antiviral. It is herein described the preparation of a series of twenty-seven benzophenone derivatives bearing 1,2,3-triazole functionalities and the evaluation of their photoprotective, cytotoxic and antiviral on Zika Virus (ZIK
Quím. Nova. Publicado em: 18/07/2019
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4. Evaluation of anxiolytic-like effect of 7-epiclusianone isolated from Garcinia brasiliensis in mice
ABSTRACT Garcinia brasiliensis Mart., Clusiaceae, species became the target of studies for some years because it has several compounds including polyprenylated benzophenones, as 7-epiclusianone. This benzophenone has several properties, such as leishmanicidal, anti-inflammatory and antinociceptive effects, however still did not be studied anxiolytic activity
Rev. bras. farmacogn.. Publicado em: 2018-06
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5. CHEMICAL COMPOSITIONS AND ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF PROPOLIS PRODUCED BY Frieseomelitta longipes AND Apis mellifera BEES
In this study, we investigated the chemical compositions and antioxidant and antimicrobial activities of propolis produced by the stingless bee Frieseomelitta longipes and the honeybee Apis mellifera collected from colonies in North Brazil. In terms of volatile composition, both mono- and sesquiterpenes were detected in the propolis of F. longipes while only
Quím. Nova. Publicado em: 2018-05
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6. Clusia criuva Cambess. (Clusiaceae): anatomical characterization, chemical prospecting and antioxidant activity
ABSTRACT This study aims the anatomical description and chemical characterization of aerial parts of Clusia criuva Cambess., Clusiaceae in addition to the evaluation of the antioxidant activity of crude extracts, correlated to the flavonoid content. The morphological characterization was performed using traditional techniques of plant anatomy. For phytochemi
An. Acad. Bras. Ciênc.. Publicado em: 31/07/2017
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7. Layered Zinc Hydroxide Salts Intercalated with Anionic Surfactants and Adsolubilized with UV Absorbing Organic Molecules
Two anionic surfactants, dodecylsulfate (DDS) and dodecylbenzenesulfonate (DBS), were intercalated into layered zinc hydroxide salts (LHS) using the direct alkaline co-precipitation method, and characterized by powder X-ray diffraction (PXRD), Fourier-transform infrared (FTIR) and thermogravimetric analysis/differential thermal analysis (TGA/DTA). Different
J. Braz. Chem. Soc.. Publicado em: 2015-09
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8. Chemosystematic aspects of polyisoprenylated benzophenones from the genus Clusia
Derivados de benzofenonas despertam grande interesse científico. A família Clusiaceae é conhecida por produzir grandes quantidades dessas substâncias, com vários resíduos isoprênicos em suas estruturas, os quais são responsáveis pela complexidade e variedade estrutural observada nesta classe de substâncias, e também contribuem para suas atividades
An. Acad. Bras. Ciênc.. Publicado em: 2015-03
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9. Growth curve, biochemical profile and phytochemical analyses in calli obtained from the procambium segments of Bacupari
Garcinia brasiliensis, popularly known as Bacupari, is native to the Amazon and commonly used in folk medicine for its therapeutic properties. This plant is rich in bioactive compounds like benzophenones. However, there are no works about the in vitro establishment and achievement of secondary metabolites in this plant. Thus, the aim of this work was to dete
Braz. arch. biol. technol.. Publicado em: 25/02/2014
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10. Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves t
Revista Brasileira de Farmacognosia. Publicado em: 12/08/2011
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11. Anti-carie and antiproliferative effect of 7-epiclusianone, isolated from Rheedia genus plant / Avaliação das atividades anticarie e antiproliferativa da 7-epiclusianona isolada da planta do genero Rheedia
Considering the great use of plants as medicinal substances in the popular medicine, it is critical to investigate their biological and chemical properties in order to not only help to enhance our understanding of the therapeutic potential of these natural products, but also how to make them more effective pharmacological agents. The enormous biodiversitiy o
Publicado em: 2008
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12. Effects of Brazilian propolis on Leishmania amazonensis
Leishmaniasis, an endemic parasitosis that leads to chronic cutaneous, mucocutaneous or visceral lesions, is part of those diseases, which still requires improved control tools. Propolis has shown activities against different bacteria, fungi, and parasites. In this study we investigated the effect of four ethanolic extracts of typified propolis collected in
Memórias do Instituto Oswaldo Cruz. Publicado em: 23/02/2007