Biology Therapy
Mostrando 1-12 de 139 artigos, teses e dissertações.
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1. Editorial Comment: Effect of Behavioral and Pelvic Floor Muscle Therapy Combined With Surgery vs Surgery Alone on Incontinence Symptoms Among Women With Mixed Urinary Incontinence: The ESTEEM Randomized Clinical Trial
ABSTRACT Objective To assess the association between prostate volume index (PVI), and prostatic chronic inflammation (PCI) as predictors of prostate cancer (PCA). PVI is the ratio between the central transition zone volume (CTZV) and the peripheral zone volume (PZV). Materials and methods Parameters evaluated included age, prostate specific antigen (PSA)
Int. braz j urol.. Publicado em: 2020-08
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2. Priorities in testis cancer care during Covid-19 Pandemic
ABSTRACT Introduction: There is little information on how to prioritize testis cancer (TC) patients' care during COVID-19 pandemic in order to relieve its pressure on the health care systems. Objective: To describe the recommendations for diagnosis, treatment and follow-up of patients with TC amidst COVID- 19 pandemic. Material and Methods: Pubmed search
Int. braz j urol.. Publicado em: 2020-07
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3. Targeted therapy with a selective BCL-2 inhibitor in older patients with acute myeloid leukemia
ABSTRACT Background: Older patients with acute myeloid leukemia are particularly difficult to treat, as they have a high risk of comorbidities, poor performance status and less tolerability to chemotherapy, as well as a more aggressive disease biology, responsible for the resistance to treatment. There is a need to explore novel therapeutic agents that are
Hematol., Transfus. Cell Ther.. Publicado em: 10/06/2019
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4. Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the
Braz. J. Psychiatry.. Publicado em: 11/10/2018
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5. Peeling the onion: the outer layers of Cryptococcus neoformans
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristic
Mem. Inst. Oswaldo Cruz. Publicado em: 07/05/2018
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6. Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challenges
ABSTRACT Human epidermal receptors (HER1/2/3/4) belong to the class of receptor-type tyrosine kinases. After binding a ligand, dimerization, it will ocurr activation of intracellular kinases after two-dimensional and cytoplasmic tail reciprocal transphosphorylation. This transphosphorylation recruits signaling pathways such as Ras/Raf/MEK/Erk1-2, PI3-K/AKT a
Braz. J. Pharm. Sci.. Publicado em: 20/07/2017
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7. Cutaneous primary B-cell lymphomas: from diagnosis to treatment
AbstractPrimary cutaneous B-cell lymphomas are a heterogeneous group of mature B-cells neoplasms with tropism for the skin, whose biology and clinical course differ significantly from the equivalent nodal lymphomas. The most indolent forms comprise the primary cutaneous marginal zone and follicle center B-cell lymphomas that despite the excellent prognosis h
An. Bras. Dermatol.. Publicado em: 2015-10
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8. Management framework paradigms for disorders of sex development
Until 2005, questions regarding medical treatment and diagnostic information on Disorders of Sex Development (DSD) were not systematically discussed with both the patients and their families; however, the way these patients are currently treated have been changing with time. Interventional changes in the clinical-psychotherapeutic-surgical areas of DSD deter
Arch. Endocrinol. Metab.. Publicado em: 28/08/2015
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9. Motivating medical students to learn basic science concepts using chronic myeloid leukemia as an integration theme
Objective: To report on the use of chronic myeloid leukemia as a theme of basic clinical integration for first year medical students to motivate and enable in-depth understanding of the basic sciences of the future physician. Methods: During the past thirteen years we have reviewed and updated the curriculum of the medical school of the Universidade Estadu
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-02
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10. Pharmacological management of osteogenesis
Osteogenesis and bone remodeling are complex biological processes that are essential for the formation of new bone tissue and its correct functioning. When the balance between bone resorption and formation is disrupted, bone diseases and disorders such as Paget's disease, fibrous dysplasia, osteoporosis and fragility fractures may result. Recent advances in
Clinics. Publicado em: 2014-06
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11. Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions
The standard of care therapy of chronic hepatitis C with the combination of pegylated interferon and ribavirin for 24 or 48 weeks was a remarkable accomplishment of the past decade. However, sustained virological responses rates of about 80% (genotypes 2-3) and 50% (geno 3 type 1) were not satisfactory especially for patients infected with genotype 1. Import
Braz J Infect Dis. Publicado em: 2013-04
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12. Pediatric anxiety disorders: from neuroscience to evidence-based clinical practice
The objective of this narrative review of the literature is to describe the epidemiology, etiology, pathophysiology, diagnosis, and treatment of pediatric anxiety disorders. We aim to guide clinicians in understanding the biology of anxiety disorders and to provide general guidelines for the proper diagnoses and treatment of these conditions early in life. A
Rev. Bras. Psiquiatr.. Publicado em: 2013