Cell Signalling
Mostrando 1-12 de 545 artigos, teses e dissertações.
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1. Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives
SUMMARY INTRODUCTION: Acute kidney injury (AKI) is highly prevalent today. It has a multifactorial aetiology and affects people of all ages, genders and ethnicities. Its treatment is essentially supportive of renal function substitution, so new treatment alternatives such as mesenchymal stem cell therapy (MSCs) should be investigated. METHODS: This review
Rev. Assoc. Med. Bras.. Publicado em: 13/01/2020
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2. ADP-ribosylation: from molecular mechanisms to human disease
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribos
Genet. Mol. Biol.. Publicado em: 13/12/2019
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3. Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy
BACKGROUND The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on the progression of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi. OBJECTIVE To evaluate the effects of oral t
Mem. Inst. Oswaldo Cruz. Publicado em: 16/07/2018
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4. Mir-190b negatively contributes to the Trypanosoma cruzi- infected cell survival by repressing PTEN protein expression
Chagas disease, which is caused by the intracellular protozoanTrypanosoma cruzi, is a serious health problem in Latin America. The heart is one of the major organs affected by this parasitic infection. The pathogenesis of tissue remodelling, particularly regarding cardiomyocyte behaviour after parasite infection, and the molecular mechanisms that occur immed
Mem. Inst. Oswaldo Cruz. Publicado em: 2015-12
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5. Influence of the Paracoccidioides brasiliensis14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells
The fungal strain Paracoccidioides brasiliensisremains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the molecules that participate in this process remained unknown. Thus, this study evaluated the contribution of two P. brasiliensismolecules, the 14-3-3 and glycoprotein of 43 kDa proteins, which had been p
Mem. Inst. Oswaldo Cruz. Publicado em: 02/06/2015
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6. Lack of AHL-based quorum sensing in Pseudomonas fluorescens isolated from milk
Numerous bacteria coordinate gene expression in response to small signalling molecules in many cases known as acylhomoserine lactones (AHLs), which accumulate as a function of cell density in a process known as quorum sensing. This work aimed to determine if phenotypes that are important to define microbial activity in foods such as biofilm formation, swarmi
Braz. J. Microbiol.. Publicado em: 2014-09
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7. Study of Vaccinia and Cowpox viruses' replication in Rac1-N17 dominant-negative cells
Interfering with cellular signal transduction pathways is a common strategy used by many viruses to create a propitious intracellular environment for an efficient replication. Our group has been studying cellular signalling pathways activated by the orthopoxviruses Vaccinia (VACV) and Cowpox (CPXV) and their significance to viral replication. In the present
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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8. Análise de genes diferencialmente expressos nas vias de sinalização (Hedgehog e Wnt) em carcinomas basocelulares humanos
Hedgehog (HH) and Wingless-Int (Wnt) signaling pathway are related to the process of cellular proliferation, differentiation, angiogenesis, matrix remodeling and homeostasis of stem cells. Over the years, several mutations in HH signaling pathway have been identified, including the loss of function mutations in ptch1 and the gain of function mutations in smo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/04/2012
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9. Atividade física e suplementação nutricional de leucina associadas ao crescimento tumoral : estudo do perfil hormonal de ratos implantados com carcinossarcomia de Walker 256 / Physical activity and nutritional supplementation with leucine associated with tumor growth : study of hormonal profile in Walker 256
The cancer-cachexia is characterized by the development of anorexia, asthenia, weight loss, early satiety, anaemia and especially changes in the metabolism of carbohydrate, fat and protein in these cancer patients. The amino acid leucine acts promoting cell signalling by inhibiting the protein catabolism and stimulating the protein synthesis in skeletal musc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012
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10. Avaliação do perfil de aminoácidos fetal e materno e atividade placentária em camudongas NMRI portadoras do adenocarcinoma de colon (MAC16) submetidas com dieta rica em leucina / Evaluation of maternal and fetal amino acid profile and placental activity in NMRI mice infected with colon adenocarcinoma (MAC 16) feeding wint leucine-rich diet
Pregnancy is a complex process involving several physiological steps and some clinical complications can alter the homeostasis adjustments during this process. Among the complications during pregnancy, cancer is very important for its coexistence than the incidence with this complex metabolic condition. In tumour-bearing mother, there is possible nutritional
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012
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11. Differential expression of the costimulatory molecules CD86, CD28, CD152 and PD-1 correlates with the host-parasite outcome in leprosy
Leprosy is a spectral disease exhibiting two polar sides, namely, lepromatous leprosy (LL) characterised by impaired T-cell responses and tuberculoid leprosy in which T-cell responses are strong. Proper T-cell activation requires signalling through costimulatory molecules expressed by antigen presenting cells and their ligands on T-cells. We studied the infl
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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12. O ß-hidroxibutirato modifica os processos de ativação e inativação dos canais para sódio e potássio em corpos celulares de neurônios dos gânglios das raizes dorsais de ratos.
Under physiological conditions, the ketone bodies -hydroxybutyrate, acetoacetate and acetone are products of -oxidation of fatty acids that occurs in hepatocytes in response to hypoglycemia. This process occurs during fasting, high fat diets (such as the ketogenic diet, used in cases of drug-resistant epilepsy) and during diabetes mellitus in order to meet t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011