Cellular Selectivity
Mostrando 1-12 de 131 artigos, teses e dissertações.
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1. “Half-Sandwich”/RuII Anticancer Complexes Containing Triphenylphosphine and p-Substituted Benzoic Acids
Mononuclear and binuclear RuII/arene/triphenylphosphine complexes with p-substituted benzoic acid derivatives were prepared and characterized. These monocationic complexes of type [Ru(η6-p-cymene)(PPh3)L] (L = benzoic acid (1), p-hydroxybenzoic acid (2), p-nitrobenzoic acid (3) and terephthalic acid (4)) were characterized using various techniques, such as
J. Braz. Chem. Soc.. Publicado em: 2020-11
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2. In vitro Anti-HMPV Activity of New Synthetic Phenytoin Derivatives
New derivatives of synthetic 5,5-diphenylhydantoin (phenytoin) were prepared by N-alkylation with 1,3-dibromopropane. Subsequent treatment with sodium azide led to the respective azide. Reaction of the azide with phenylacetylene and 2-hydroxy-3-butyne and oxidation of the resulting alcohol with MnO2 resulted in three triazolic compounds that were evaluated i
J. Braz. Chem. Soc.. Publicado em: 2016-01
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3. Superfícies de titânio modificadas termoquimicamente por plasma : avaliação da resposta biológica
Este estudo laboratorial envolveu a participação de um grupo de profissionais de áreas distintas, as quais contribuíram na construção de um conhecimento multidisciplinar, acerca da resposta biológica de superfícies de titânio modificadas por tratamento termoquímico a plasma. Para tanto, uma avaliação da análise de fase cristalina, topografia, ru
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2011
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4. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available drugs are unsatisfactory. Aromatic compounds represent an important class of DNA minor groove-binding lig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-05
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5. Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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6. Neurotoxic activity and ultrastructural changes in muscles caused by the brown widow spider Latrodectus geometricus venom
Brown widow spider (Latrodectus geometricus) venom (BrWSV) produces few local lesions and intense systemic reactions such as cramps, harsh muscle pains, nausea, vomiting and hypertension. Approximately 16 protein bands under reducing conditions and ~ 14 bands under non-reducing conditions on a 12.5% sodium dodecyl sulfate-polyacrylamide gel electrophoresis w
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2009-04
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7. Estudo do Segmento Consenso Adjacente ao Domínio TM2 e parte do Domínio TM2 do Receptor P2X7: Dinâmica Molecular e Atividade de Canal Iônico. / Study of the segment adjacent consensus to domain TM2 and part of domain TM2 of receiver P2X7: molecular dynamics and activity of ionic canal.
The purinergic receptor P2X7 (P2X7R) is a membrane protein which forms channels in the presence of extracellular ATP. Once opened, the channels allow the transport of cations through the cellular membrane, being expressed preferentially in immune cells. Among all purinergic receptors, P2X7R has distinct characteristics from other P2X (P2XR) members. For exam
Publicado em: 2007
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8. POTENCIAL ANTIMICROBIANO DE EXTRATOS, FRAÇÕES E COMPOSTOS PUROS OBTIDOS DE ALGUMAS PLANTAS MEDICINAIS BRASILEIRAS / ANTIMICROBIAL POTENTIAL OF EXTRACTS, FRACTIONS AND PURE COMPOUNDS FROM SOME PLANTS OF THE CATARINENSE FLORA
In this study, we have evaluated the antimicrobial activity from some plants of the catarinense flora (Abuta sellowana, Calophyllum brasiliense, Coussapoa schottii, Ipomoea pes-caprae, Psyhotria spp., Quiina spp.,Sloanea spp, and the plant known popularly as Lírio do Campo) and the pure compounds isolated from Adiantum cuneatum (filiceno and filicenol), for
Publicado em: 2005
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9. QUANTIFICATION OF REDUCED GLUTATHIONE IN HUMAN ERYTHROCYTES BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-UV: VALIDATION AND APLICATION / QUANTIFICAÇÃO DA GLUTATIONA REDUZIDA EM ERITRÓCITOS HUMANOS POR CROMATOGRAFIA LÍQUIDA DE ALTA EFICIÊNCIA-UV: VALIDAÇÃO E APLICAÇÃO
Oxidative stress may be initiated by a decline in the antioxidant defence system or by an overproduction of free radicals leading to an imbalance between oxidants and antioxidants. The most significant alteration in the antioxidant defence is a decrease in reduced glutathione (GSH) concentration. GSH depletion is linked to a number of disease states; includi
Publicado em: 2005
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10. Design and applications of modified oligonucleotides
Oligonucleotides have a wide range of applications in fields such as biotechnology, molecular biology, diagnosis and therapy. However, the spectrum of uses can be broadened by introducing chemical modifications into their structures. The most prolific field in the search for new oligonucleotide analogs is the antisense strategy, where chemical modifications
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-02
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11. PurificaÃÃo parcial de uma lectina da raiz de Guettarda platypoda
Lectins, proteins or glycoproteins that reversible bind carbohydrates with distinct degrees of selectivity, they are found in a variety of organisms being involved in numerous cellular processes. In this work evaluated the presence of lectin(s) from Guettarda platypoda D.C., plant popular know with âangelicaâ. Roots of this plant have been used in folk med
Publicado em: 2003
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12. Caracterização de disintegrinas de venenos viperídeos como ferramentas seletivas na detecção ou inibição da função de integrinas / Characterization of viper venom disintegrins as tools for detecting and inhibiting integrin function
Integrins are membrane proteins involved in biological processes such as embriogenesis, inflammation and platelet aggregation. The alteration of their expression pattem is related to pathological disorders such as thrombosis and cancer, making integrins suitable indicators of the progression of these diseases. Thus, the α2β1 integrin, which is expr
Publicado em: 2003