Coenzyme Q10
Mostrando 1-12 de 55 artigos, teses e dissertações.
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1. The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study
ABSTRACT Purpose: Sperm DNA fragmentation (SDF) and seminal oxidative stress are emerging measurable factors in male factor infertility, which interventions could potentially reduce. We evaluated (i) the impact of lifestyle changes combined with oral antioxidant intake on sperm DNA fragmentation index (DFI) and static oxidation-reduction potential (sORP), a
International braz j urol. Publicado em: 2022
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2. Duchenne muscular dystrophy: an historical treatment review
RESUMO Nesta revisão são discutidas as terapêuticas empregadas no tratamento da distrofia muscular de Duchenne desde a descrição da doença. Apresentamos as diversas teorias que fundamentaram as intervenções terapêuticas, com uma breve descrição dos tipos de avaliação empregados nos ensaios terapêuticos. Dentre todos os tratamentos, a única med
Arq. Neuro-Psiquiatr.. Publicado em: 05/09/2019
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3. Coenzyme Q10 in the Treatment of Mitochondrial Disease
Abstract Currently, there is a paucity of available treatment strategies for oxidative phosphorylation disorders. Coenzyme Q10 (CoQ10) and related synthetic quinones are the only agents to date that have proven to be beneficial in the treatment of these heterogeneous disorders. The therapeutic efficacy of CoQ10 is not restricted to patients with an underlyin
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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4. Use of Idebenone for the Treatment of Leber’s Hereditary Optic Neuropathy
Abstract Leber’s hereditary optic neuropathy (LHON) is one of the most frequent mitochondrial disorders. It is caused by mutations in genes of the mitochondrial DNA coding for subunits of the respiratory chain and leads to severe bilateral vision loss, from which spontaneous recovery is infrequent. Retinal ganglion cells show a selective vulnerability to m
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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5. The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes
Resumo Objetivo: Avaliar o estado antioxidante da vitamina E no plasma e da coenzima Q10 no plasma e intracelular em crianças com diabetes tipo 1. Método: Este estudo caso-controle realizado em com 72 crianças com diabetes tipo 1 comparadas por idade, sexo e etnia de 58 crianças saudáveis. As crianças diabéticas foram divididas em dois grupos de aco
J. Pediatr. (Rio J.). Publicado em: 11/04/2019
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6. Cold-Induced Ascites in Broilers: Effects of Vitamin C and Coenzyme Q10
ABSTRACT We hypothesized that the supplementation of vitamin C (Vit. C) and coenzyme Q10 (CoQ10) alone or in combination could reduce the negative effects of cold stress in broilers. Four hundred male chicks were exposed for 24 h to cold stress (15 ºC) starting from 15d of age, while a positive control group (PC, 100 birds) was kept under normal temperature
Rev. Bras. Cienc. Avic.. Publicado em: 2017-09
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7. Carcass Traits and Immune Response of Broiler Chickens Fed Dietary L-Carnitine, Coenzyme Q10 and Ractopamine
ABSTRACT This study was conducted to evaluate the effects of coenzyme Q10, L-carnitine and ractopamine supplementation, alone and in combinations, on carcass traits and immune response of broiler chickens. Five hundred and twelve one-day-old Ross 308 male broiler chickens were randomly allocated into eight treatments with four replicates each. A 2×2×2 fact
Rev. Bras. Cienc. Avic.. Publicado em: 2016-12
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8. Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of the polyglutamine domain of the ataxin-3 (ATX3) protein. MJD/SCA3 is the most frequent autosomal dominant ataxia in many countries. The mechanism underlying MJD/SCA3 is thought to be mainly related to protein misfold
Braz J Med Biol Res. Publicado em: 21/11/2016
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9. Estudo da toxicidade muscular pelo uso de estatinas em pacientes hipercolesterolêmicos: avaliação pela espectroscopia do hidrogênio por ressonância magnética / Study of muscle toxicity by use of statins in hypercholesterolemic patients: evaluation by proton magnetic resonance spectroscopy
Cardiovascular disease is the leading cause of death in the western world and statins are the most prescribed medications for prevention and treatment. Despite being the most prescribed drugs, they are still under-used. The main cause of interruption of statin treatment is myopathy. Among the mechanisms involved in the pathophysiology of myotoxicity, deficie
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/11/2012
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10. A síntese de coenzima Q e a estabilidade de DNA mitocondrial em Saccharomyces cerevisiae. / The synthesis of coenzyme Q and stability of mitochondrial DNA in Saccharomyces cerevisiae.
Mutantes respiratórios de Saccharomyces cerevisiae podem apresentar uma ampla variedade de instabilidade do mtDNA. Nós analisamos diferentes classes de mutantes e observamos uma elevada instabilidade nos mutantes que não possuem a coenzima Q (CoQ) funcional. O objetivo desse trabalho foi avaliar os efeitos das alterações no estado redox da coenzima Q so
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/06/2012
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11. Beneficial effect of ubiquinol, the reduced form of coenzyme Q10, on cyclosporine nephrotoxicity
BACKGROUND: Cyclosporine (CyA) nephrotoxicity is partly due to some oxidative stress. Ubiquinol, the reduced form of coenzyme Q10 (rCoQ10), has recently gained attention for its anti-oxidative potential. The aim of this study is to evaluate the effect of rCoQ10 on a CyA nephrotoxic rat model. MATERIALS AND METHODS: Six-week-old male Wistar rats were divided
International braz j urol. Publicado em: 2012-04
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12. Possíveis efeitos citoprotetores do antioxidante da dieta coenzima Q10 em modelo de células neuronais / Possible cytoprotective effects of the dietary antioxidant coenzyme Q10 in a neuronal cell model
A coenzima Q10 é uma provitamina lipossolúvel sintetizada endogenamente e naturalmente encontrada em alimentos como a carne vermelha, peixes, cereais, brócolis e espinafre. É comercializada como suplemento alimentar e utilizada em formulações cosméticas. Localiza-se na membrana de organelas celulares como retículo endoplasmático, vesículas e membra
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/10/2011