Colorectal Carcinogenesis
Mostrando 1-12 de 43 artigos, teses e dissertações.
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1. The Prognostic Roles of PYCR2 and ZBTB18 Expression in Tissues of Colorectal Carcinoma and Non-Neoplastic Tissues: An Immunohistochemical Study
Abstract Background It is important to detect novel biomarkers responsible for the progression and spread of colorectal cancer (CRC) to better evaluate the prognosis of the patients, provide better management, and foster the development of therapeutic targets. In humans, pyrroline-5-carboxylate reductase 2 (PYCR2) is encoded on chromosome 1q42.12, and its m
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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2. IS SUPERFICIAL COLORECTAL LESIONS WITH LOW AND HIGH GRADES INTRAEPITHELIAL NEOPLASMS MORE PREVALENT IN OLDER ABOVE 65 YEARS?
RESUMO Racional: O câncer colorretal tem maior incidência no reto e sigmoide. Porém, com a ampliação do diagnóstico das lesões superficiais do cólon e reto tem-se aumentado o interesse por elas no diagnóstico e no papel que elas representam na carcinogênese colorretal. Objetivo: Verificar o comportamento das lesões superficiais do cólon e reto,
ABCD, arq. bras. cir. dig.. Publicado em: 20/12/2019
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3. The role of Phosphatidylinositol 3 kinase (PI3K) and Cycloxygenase-2 (COX2) in carcinogenesis of colorectal polyps
RESUMO Objetivos: Determinar a expressão imuno-histoquímica de Fosfatase homóloga a tensina (PTEN), Fosfatidilinositol-3-cinase (PI3K), Ciclooxigenase-2 (COX2) e um marcador de proliferação (Ki67) em pólipos colorretais e correlacionar com dados clínicos e patológicos buscando sua correspondência na carcinogênese. Métodos: Revisados 297 pólipos
J. Coloproctol. (Rio J.). Publicado em: 2018-03
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4. Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Abstract Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the
Genet. Mol. Biol.. Publicado em: 19/02/2018
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5. High occurrence of Fusobacterium nucleatum and Clostridium difficile in the intestinal microbiota of colorectal carcinoma patients
Abstract Colorectal carcinoma is considered the fourth leading cause of cancer deaths worldwide. Several microorganisms have been associated with carcinogenesis, including Enterococcus spp., Helicobacter pylori, enterotoxigenic Bacteroides fragilis, pathogenic E. coli strains and oral Fusobacterium. Here we qualitatively and quantitatively evaluated the pres
Braz. J. Microbiol.. Publicado em: 09/10/2015
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6. Ponderal behavior of rats fed an omegas 3, 6 and 9 enriched diet submitted to colon carcinogenesis induced by azoxymethane
PURPOSE: To assess weight changes in rats fed diets with different ratios of omegas 3, 6 and 9 submitted to colonic carcinogenesis induced by Azoxymethane (AOM). METHODS: Sixty rats with three weeks of life were distributed into five groups of specific diets containing 12 animals each: GI- Standard diet without adminstration of AOM, GII- Standard diet with a
Acta Cir. Bras.. Publicado em: 2013-10
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7. Thymosin ß4 expression in colorectal polyps and adenomas
OBJECTIVE: Thymosin beta 4 (Tβ4) is a ubiquitous peptide that plays pivotal roles in the cytoskeletal system and in cell differentiation. Recently, a role for Tβ4 has been proposed in experimental and human carcinogenesis, including gastrointestinal cancer. This study was aimed at evaluating the relationship between Tβ4 immunoreactivity and the initial s
Clinics. Publicado em: 2013-09
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8. Expressão imunoistoquímica da proteína C reativa no adenocarcinoma de reto
O possível envolvimento da inflamação na carcinogênese colorretal tem potenciais implicações prognósticas, preventivas e terapêuticas. Foi investigado, através de imunoistoquímica, se a proteína C reativa (PCR) é expressa em adenocarcinoma retal primário humano, e avaliada sua relação com achados clínico-patológicos. Acúmulo celular de PCR
Publicado em: 2008
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9. Estudo da ação antineoplástica do ipê roxo na carcinogênege induzida pelo azoximetano em camundongos
The Purple Ipe (Tabebuia avellanedae), a tree of the Bignoniacea family found in Brazil, is known by the popular medicine as antitumoral agent against some neoplasias, between them the colorretal cancer. The objective of the present work is experimentally to study the antitumoral action of β- lapachone, that is an extracted constituent of purple ipe, in
Publicado em: 2007
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10. Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis
Trypanosoma cruzi infection and nonsteroidal anti-inflammatory drugs inhibit colorectal carcinogenesis by mechanisms not completely known and metallothionein proteins (MTs) may be involved in this process. Sixty-six male Wistar rats weighing 90 to 120 g were randomly divided into seven groups (GI to GVII). GI, GII and GIII animals were subcutaneously infecte
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-07
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11. Determination of Cyclin G expression in rectal cancer / Determinação da expressão da Ciclina G no câncer do reto
Introduction: Identification of genetic mechanisms involved in colorectal cancer carcinogenesis led to the development of new treatment strategies such as gene therapy. The aim of this strategy is to interrupt cell-cycle of transformed malignant cells by blocking or stimulating specific gene expression. Utilization of cyclin G antisense constructs has been s
Publicado em: 2006
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12. Interferências de ácidos graxos ômega-3 e vitamina E na carcinogênese experimental do cólon / Interference of omega-3 fatty acids and vitamin E with experimental colon carcinogenesis
O câncer colorretal ocupa um lugar de destaque mundial devido à sua alta incidência, sendo um dos tipos de câncer mais afetado pela dieta. Estudos experimentais sustentam a hipótese de que ácidos graxos [ômega]-6 contribuem para o desenvolvimento do câncer colorretal, enquanto os ácidos graxos da série [ômega]-3 possuem ação protetora. Entretant
Publicado em: 2006