Conjugate Analysis
Mostrando 1-12 de 157 artigos, teses e dissertações.
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1. Trajectory of serogroups causing Invasive Meningococcal Disease in Santa Catarina state, Brazil (2007–2019)
Abstract The aim of this study was to compare the trajectory of serogroups causing Invasive Meningococcal Disease (IMD) in the Santa Catarina (SC) state with those of whole Brazil. A retrospective analysis of all IMD cases reported from January 2007 to December 2019 was carried out. During the study period, 26,058 IMD cases were registered in Brazil and 644
Braz J Infect Dis. Publicado em: 2020-08
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2. Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy
Abstract Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration compromised the field of its advancement. Single chai
Genet. Mol. Biol.. Publicado em: 17/01/2020
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3. Avaliação dos processos de fratura em filmes finos através da simulação de ensaios de indentação com penetradores esféricos
RESUMO Recentes trabalhos propõem a utilização dos ensaios de indentação como uma ferramenta capaz de avaliar características mecânicas de filmes finos, assim como avaliar possíveis falhas em sistemas que conjugam filmes de alta dureza depositados em substratos metálicos em solicitações tribológicas. Entretanto, a implementação da técnica de i
Matéria (Rio J.). Publicado em: 25/11/2019
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4. The direct and indirect effects of the pneumococcal conjugated vaccine on carriage rates in children aged younger than 5 years in Latin America and the Caribbean: a systematic review
RESUMO Objetivo Demonstrar o impacto das vacinas pneumocócicas conjugadas no estado de portador de Streptococcus pneumoniae em crianças menores de 5 anos na América Latina e no Caribe. Métodos Foi realizada revisão sistemática da literatura sobre os efeitos diretos e indiretos da vacina pneumocócica no estado de portador em crianças menores de 5 an
Einstein (São Paulo). Publicado em: 25/11/2019
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5. Analytical Solution for Optimal Low-Thrust Limited-Power Transfers Between Non-Coplanar Coaxial Orbits
ABSTRACT: In this paper, an analytical solution for time-fixed optimal low-thrust limited-power transfers (no rendezvous) between elliptic coaxial non-coplanar orbits in an inverse-square force field is presented. Two particular classes of maneuvers are related to such transfers: maneuvers with change in the inclination of the orbital plane and maneuvers wit
J. Aerosp. Technol. Manag.. Publicado em: 03/05/2018
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6. Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy
BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities. Antibodies against several Mycobacterium leprae antigens have, however, shown value as diagnostic and/or prognostic markers. OBJECTIVES The objective of this study was to evaluate serum immunoglobulin
Mem. Inst. Oswaldo Cruz. Publicado em: 26/02/2018
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7. Clinical and microbiological implications of invasive pneumococcal disease in hospitalized patients (1998–2013)
Abstract Introduction Infections caused by Streptococcus pneumoniae (pneumococcus) still represent a challenge for health systems around the world. Objective The objective of this study was to assess microbiological and clinical aspects in hospitalized patients with invasive pneumococcus disease between 1998 and 2013. Materials and methods This was a retr
Braz J Infect Dis. Publicado em: 2016-06
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8. Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation
The aim of this study was to develop a theoretical model using Anopheles gambiae GSTE2 structure as template for Aedes aegypti GSTE2 by homology modeling Docking simulations were performed for both the enzymes against usnic acid in neutral and anionic forms. Ramachandran plot revealed that 93.9% of the GSTE2 model residues were located on most favored region
Braz. arch. biol. technol.. Publicado em: 2014-10
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9. Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni
Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an important role in Ub-depen
Mem. Inst. Oswaldo Cruz. Publicado em: 04/11/2013
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10. Iniciativas de atendimento para crianças negras na província de São Paulo (1871-1888) / Care initiatives for Black children in the province of São Paulo (1871-1888).
The text discusses the care of children free for the period 1871 to 1879 in the province of São Paulo. The theme is relevant to research in the field of educational historiography and the history of Brazilian children in order to understand the care initiatives proposed by the province of Sao Paulo to the sons and daughters of enslaved families. Throughout
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/04/2012
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11. Síntese e caracterização de heteropentâmeros formados por cobaltoftalocianina e cobaltotetrafenilporfirina
Metalloporphyrins and metalophthalocyanines assemblies have attracted in the last few decades. The syntheses of face to face systems containing porphyrins or phthalocyanines can found in literature, however few works reported these arrangements in mixed systems. A new system composed by cobaltophthalocyanine (CoPc) and cobaltotetraphenylporphyrin (CoTPP) ass
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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12. A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumor growth
Doxorubicin (DOX) was conjugated to a single-chain variable fragment (scFv) against human midkine (MK), and the conjugate (scFv-DOX) was used to target the chemotherapeutic agent to a mouse solid tumor model in which the tumor cells expressed high levels of human MK. The His-tagged recombinant scFv was expressed in bacteria, purified by metal affinity chroma
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03