Connexin 32
Mostrando 1-12 de 59 artigos, teses e dissertações.
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1. Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation
Hepatocellular carcinoma (HCC) is the third highest cause of cancer death worldwide. In general, the disease is diagnosed at an advanced stage when potentially curative therapies are no longer feasible. For this reason, it is very important to develop new therapeutic approaches. Retinoic acid (RA) is a natural derivative of vitamin A that regulates important
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
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2. O MODELO DESMIELINIZANTE DO BROMETO DE ETÍDIO (BE): ESTUDOS MORFOLÓGICOS EM CAMUNDONGOS C57BL/6 NORMAIS E KNOCKOUT PARA CONEXINA 32 / ETHIDIUM BROMIDE (EB) DEMYELINATING MODEL: MORPHOLOGIC STUDIES IN C57BL/6 NORMAL AND CX 32 KNOCKOUT MICE
Light and ultraestructural changes of central and peripheral nervous system lesions in mice KO for connexin-32 and submitted to the ethidium bromide gliotoxic demyelinating model are described. Their KO condition was tested with PCR and a negative connexin-32 labelling was performed by immunofluorescence. The experimental animals were C57BL/6 normal mice and
Publicado em: 2007
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3. Estudo retrospectivo-sistemático e análise quantitativa da proliferação celular e apoptose; identificação da proteína conexina 43 e 26 aberrante em glândula perianal normal, hiperplásica e neoplásica em cães / Retrospective - systematic study and quantitative analysis of the cellular proliferation and apoptosis and identification of connexin 43 and aberrant 26 protein in normal, hyperplasic and neoplastic perianal glands in dogs
Two hundred and forty five neoplasms of the perianal glands of dogs from the archives of the Department of Pathology of the FMVZ/USP, 1984 to 2004, have been reviewed hystologically. Most of the cases (34%) were classified as moderately differentiated adenomas, group II, in males over 8 years of age, which showed an androgenic dependence of these neoplasms.
Publicado em: 2006
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4. Emissões otoacusticas evocadas por estímulo trasiente em recém-nascidas homozigotos normais e heterozigotos para a mutação 35delg no gene da conexina / Transient Evoked otoacoustic emissions in carriers and non-carriers 35delG neonates
ABSTRACT The many areas in public health are becoming more and more united, aiming to provide better quality of life to the patients. For this reason, Audiology and Genetic are working closely, due to research which relates genetic hearing loss to hearing evaluation tests. Mutations in gene GJB2, which encodes conexin protein 26 represent the main cause of g
Publicado em: 2006
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5. Carcinogênese pulmonar em camundongos portadores de deleção em um dos alelos do gene da Cx43 / Lung carcinogenesis in mice with a deletion in one allele of Cx43 gene
Gap junctions are communicating protein channels formed between adjacent cells that allow the exchange of molecules and ions smaller than 1kDa; connexins are proteins that form these junctions. Studies in the literature have been showing the lower level of cell communication capacity and alterations in the expression and/or localization of connexins in neopl
Publicado em: 2005
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6. Expressão e distribuição da conexina 32 em fígados com fibrose experimentalmente induzida / Expression and distribution of connexin 32 in liver with experimentally induced fibrosis
The connexin 32 (Cx32) is a proteic structure that constitute the channels that promote the cell communication by means of the gap junction (GJIC), allowing the diffusion of short cytoplasmic molecules from a cell to another. This work aimed to study these structures due to their importance in the hepatic metabolic processes. The hepatic fibrosis was trigger
Publicado em: 2004
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7. Estudo de mutações no gene GJB3 como causa de deficiencia auditiva neurossensorial não-sindromica
Deafness is one of the most common sensory defects in the general population and its prevalence increases with age. In developed countries about 60% of hearing loss cases are due to genetic factors. In Brazil the majority of cases of hearing loss are due to environmental factors. However, the proportion of genetic causes tends to increase as a result of impr
Publicado em: 2003
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8. Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
The carboxyl-terminal (CT) domain of connexin43 (Cx43) has been implicated in both hormonal and pH-dependent gating of the gap junction channel. An in vitro assay was utilized to determine whether the acidification of cell extracts results in the activation of a protein kinase that can phosphorylate the CT domain. A glutathione S-transferase (GST)-fusion pro
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
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9. Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication
Connexin43 (Cx43) is a major gap junction protein present in the Fischer-344 rat aorta. Previous studies have identified conditions under which selective disruption of intercellular communication with heptanol caused a significant, readily reversible and time-dependent diminution in the magnitude of a1-adrenergic contractions in is
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
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10. Beta-caroteno e vitamina A modulam a proliferação de células ovais e a expressão gênica, para conexina 43 em modelo in vivo de diferenciação celular hepática / Beta-carotene and vitamin A modulate the oval cells proliferation and the connexin 43 gene expression at in vivo hepatic cellular differentiation model
Avaliou-se os efeitos do β-caroteno e da vitamina A sobre o processo de proliferação de células ovais em modelo de diferenciação celular hepática. Para tanto, ratos machos Wistar foram tratados com β-caroteno (grupo BC - 70 mg/kg de peso corpóreo [pc]), vitamina A (grupo VA - 10 mg/kg pc) ou óleo de milho (CO - grupo controle) por via intra
Publicado em: 1999
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11. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.
The gap junctional protein connexin32 is expressed in hepatocytes, exocrine pancreatic cells, Schwann cells, and other cell types. We have inactivated the connexin32 gene by homologous recombination in the mouse genome and have generated homozygous connexin32-deficient mice that were viable and fertile but weighed on the average approximately 17% less than w
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12. Differential expression of three gap junction proteins in developing and mature brain tissues.
By using antibodies directed against gap junction proteins of liver (connexins 26 and 32) and heart (connexin 43), we have localized immunoreactivity to specific cell types in frozen sections of adult rodent brains. Connexin 32 reactivity was found in oligodendrocytes and also in a few neurons, whereas reactivity to connexins 26 and 43 was localized to lepto