Cyclins
Mostrando 1-12 de 425 artigos, teses e dissertações.
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1. Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice
PURPOSE: To investigate the hemopreventive effect of defatted flaxseed meal in C57BL/6 mice after induction of precancerous colon lesions with 1.2-dimethylhydrazine (DMH). METHODS: Thirty-six 12-week-old C57BL/6 mice were divided into three treatment groups(n=12 in each group): (1) diet with 10% defatted flaxseed meal; (2) diet with defatted flaxseed meal an
Acta Cir. Bras.. Publicado em: 2013-08
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2. O uso de interferência por RNA para a análise da função do gene E2F1 na progressão do ciclo celular em células tumorais / Use of RNA interference for the analysis of E2F1 gene function in cell cycle progression in tumor cells
E2F1 belongs to a family of transcription factors and plays a central role in controlling the expression of genes related to regulation of the cell-cycle progression, since it activates genes involved in DNA synthesis. The activity of E2F1 is regulated by pRB protein, that when phosphorylated by cyclin-dependent kinases cyclins (Cyclins/CDK) releases this tr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/10/2010
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3. Efeito da fibra como alimento funcional na prevenção da incidência de focos de criptas aberrantes (FCA) no cólon de camundongos induzida por 1,2- dimetilhidrazina / Effect of fiber as a functional food in preventing the incidence of aberrant crypt foci (ACF) in colon of mice induced by 1,2-dimethylhydrazine
The use of healthy diets has been a great ally in the prevention and treatment of various diseases, including colorectal cancer (CRC), a disease that affects much of the world population, configuring it as a public health problem. Genetic and environmental factors are cited as the main causes of the CRC. Among the diet can highlight the environmental. The us
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2010
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4. Regulação do ciclo celular após inibição farmacológica da enzima ácido graxo sintase em linhagem derivada de melanoma murino, B16-F10 / Cell cycle regulation after pharmacological inhibition of the enzyme fatty acid synthase in murine melanoma line derived from, B16-F10
Ácido graxo sintase (FASN - fatty acid synthase) é a enzima metabólica responsável pela síntese endógena do ácido graxo saturado palmitato, a partir dos precursores acetil-CoA e malonil-CoA. Diversos estudos mostram que, em contraste com a maioria das células normais, FASN é altamente expressa em vários tipos de neoplasias malignas humanas, tais co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/07/2010
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5. Paullinia cupana Mart var. sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice
We showed that guaraná (Paullinia cupana Mart var. sorbilis) had a chemopreventive effect on mouse hepatocarcinogenesis and reduced diethylnitrosamine-induced DNA damage. In the present experiment, we evaluated the effects of guaraná in an experimental metastasis model. Cultured B16/F10 melanoma cells (5 x 10(5) cells/animal) were injected into the tail ve
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-04
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6. Expression of D-type cyclins in differentiating cells of the mouse spinal cord
The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently e
Genetics and Molecular Biology. Publicado em: 2007
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7. Determination of Cyclin G expression in rectal cancer / Determinação da expressão da Ciclina G no câncer do reto
Introduction: Identification of genetic mechanisms involved in colorectal cancer carcinogenesis led to the development of new treatment strategies such as gene therapy. The aim of this strategy is to interrupt cell-cycle of transformed malignant cells by blocking or stimulating specific gene expression. Utilization of cyclin G antisense constructs has been s
Publicado em: 2006
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8. Cloning of four cyclins from maize indicates that higher plants have three structurally distinct groups of mitotic cyclins.
While a large number of cyclins have been described in animals and yeasts, very limited information is available regarding cyclins in plants. We describe here the isolation of cDNA clones encoding four putative mitotic cyclins from maize. All four cyclins were able to induce maturation of Xenopus oocytes, demonstrating that they can act as mitotic cyclins in
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9. Redundant cyclin overexpression and gene amplification in breast cancer cells.
Cyclins are prime cell cycle regulators and are central to the control of major check points in eukaryotic cells. The aberrant expressions of two cyclins (i.e., cyclins A and D1) have been observed in some cancers, suggesting they may be involved in loss of growth control. However, in spite of these occasional changes involving only two cyclins, there are no
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10. Expression of cyclins E1 and E2 during mouse development and in neoplasia
Cyclin E1 (formerly called cyclin E) and the recently described cyclin E2 belong to the family of E-type cyclins that operate during the G1/S phase progression in mammalian cells. The two E-cyclins share a catalytic partner, cyclin-dependent kinase 2 (CDK2), and activate their associated kinase activities at similar times during cell cycle progression. Despi
The National Academy of Sciences.
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11. A family of cyclin D homologs from plants differentially controlled by growth regulators and containing the conserved retinoblastoma protein interaction motif.
A new family of three related cyclins has been identified in Arabidopsis by complementation of a yeast strain deficient in G1 cyclins. Individual members show tissue-specific expression and are conserved in other plant species. They form a distinctive group of plant cyclins, which we named delta-type cyclins to indicate their similarities with mammalian D-ty
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12. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.
Conditional overexpression of human cyclins B1, D1, and E was accomplished by using a synthetic cDNA expression system based on the Escherichia coli tetracycline repressor. After induction of these cyclins in asynchronous Rat-1 fibroblasts, a decrease in the length of the G1 interval was observed for cyclins D1 and E, consistent with an acceleration of the G