Cytoplasmic Calcium
Mostrando 1-12 de 380 artigos, teses e dissertações.
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1. Efeitos vasculares induzidos pelo peptídeo natriurético tipo C (CNP) em aorta de ratos normotensos e hipertensos renais / Vascular effects induced by C-type natriuretic peptide (CNP) on aorta from normotensive and renovascular hypertensive rats.
O peptídeo natriurético tipo C (CNP) é descrito como agonista vasodilatador do músculo liso vascular de artérias e veias, podendo ser produzido e liberado do endotélio vascular frente a diversos estímulos. Este promove o relaxamento vascular através da interação com seu receptor associado à enzima guanilil ciclase particulada (GCp) de membrana, le
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/07/2011
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2. ECA e receptor AT1 participam da mecanotransdução de sinais hemodinâmicos independentemente da angiotensina II / ACE and AT1 receptor are involved in mechanotransduction by hemodynamica forces independently of angiotensin II
Hemodynamic forces such as pressure and shear stress modulate the patophysiolgy of the cardiovascular system. In this study, we investigated two transmembranic key molecules of the renin-angiotensin system (RAS) as mechanosensors and mechanotransducers of physical forces: Angiotensin Converting Enzyme (ACE) and Angiotensin II type 1 Receptor (AT1). ACE is an
Publicado em: 2010
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3. Modulação do mecanismo de sedreção de insulina em ilhotas pancreaticas de ratos submetidos a restrição protetica e suplementados com taurina / Insulin secretion mechanisms in pancreatic islets of protein-restricted rats supplemented with taurine
Malnutrition still is a public health issue, especially in developing countries. Many studies correlate malnourishment during early life and the development of cardiovascular disease and type 2 Diabetes Mellitus on latter stages. Animal models of malnutrition reveal impaired insulin secretion stimulated by glucose and other insulinotropic agents as well as l
Publicado em: 2009
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4. Nuclear calcium signaling: a cell within a cell
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions
Brazilian Journal of Medical and Biological Research. Publicado em: 07/11/2008
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5. Funções do cálcio nuclear e citosólico na sinalização celular
Nucleoplasmic and cytoplasmic calcium (Ca2+ ) can be regulated independently. The relative contribution of nucleoplasmic and cytoplasmic Ca2+ to biological processes such as gene transcription, cell growth, apoptosis and cell cycle control remain to be -binding proteins fully defined. In order to address this question, we target the Ca2+ parvalbumin (PV) or
Publicado em: 2006
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6. CLONAGEM, CARACTERIZAÇÃO E EXPRESSÃO HETERÓLOGA DE UMA CALNEXINA HOMÓLOGA DO FUNGO PATOGÊNICO Paracoccidioides brasiliensis / Cloning, characterization and heterologue expression of a calnexin homologue from the pathogenic fungus Paracoccidioides brasiliensis. / CLONAGEM, CARACTERIZAÇÃO E EXPRESSÃO HETERÓLOGA DE UMA CALNEXINA HOMÓLOGA DO FUNGO PATOGÊNICO Paracoccidioides brasiliensis / Cloning, characterization and heterologue expression of a calnexin homologue from the pathogenic fungus Paracoccidioides brasiliensis.
We report the cloning of a Paracoccidioides brasiliensis cDNA, here named PbCnx, encoding the homologue of the endoplasmic reticulum calnexin. This chaperone specifically recognizes monoglucosylated glycoproteins in the endoplasmic reticulum. Thus, it is an essential component of the folding process of nascent secreted glycoproteins. PbCnx open reading frame
Publicado em: 2006
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7. Estudo da expressão de Antígenos Aberrantes em plasmócitos de portadores de Mieloma Múltiplo através de Citometria de Fluxo Mul-tiparamétrica / Detection of aberrant antigens in multiple myeloma cells by multiparametric flow cytometry.
The aims of this study were to determine aberrant antigens (AA) in MM cells and to evaluate their prognostic value and frequency. Methods : bone marrow plasma cells of an homogeneous cohort of 30 newly diagnosed patients with MM were studied. As normal control, bone marrow plasma cells from 4 healthy marrow do-nors were also evaluated. Surface and cytoplasmi
Publicado em: 2006
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8. Activation of a P2Y4-like purinoceptor triggers an increase in cytosolic [Ca2+] in the red blood cells of the lizard Ameiva ameiva (Squamata, Teiidae)
An increasing number of pathophysiological roles for purinoceptors are emerging, some of which have therapeutic potential. Erythrocytes are an important source of purines, which can be released under physiological and physiopathological conditions, acting on purinergic receptors associated with the same cell or with neighboring cells. Few studies have been c
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-01
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9. Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure
Infarct-induced heart failure is usually associated with cardiac hypertrophy and decreased ß-adrenergic responsiveness. However, conflicting results have been reported concerning the density of L-type calcium current (I Ca(L)), and the mechanisms underlying the decreased ß-adrenergic inotropic response. We determined I Ca(L) density, cytoplasmic calcium ([
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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10. Involvement of calcium in pain and antinociception
Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and ant
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-04
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11. Calcium exchange and ionized cytoplasmic calcium in resting and activated human monocytes.
We have performed a comprehensive study of calcium tracer flux, distribution, content, and ionized cytoplasmic calcium during monocyte activation. A model of monocyte calcium was developed from 45Ca uptake and exodus curves which indicated that cell calcium was partitioned between three compartments. The magnitude of the time constants for each pool lead us
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12. Relationship of superoxide production to cytoplasmic free calcium in human monocytes.
Calcium has been proposed as an intracellular second messenger for activation of secretion, phagocytosis, and the oxidative burst of neutrophils. We have examined the role of calcium in human monocyte activation. Concanavalin A (Con A)-stimulated monocytes displayed an increment in cytoplasmic ionized calcium at 31 +/- 6 s and the onset of superoxide product