Diamines
Mostrando 1-12 de 48 artigos, teses e dissertações.
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1. ESTUDO COMPUTACIONAL DE 1H-IMIDAZOL-2-IL-PIRIMIDINA-4,6-DIAMINAS PARA A IDENTIFICAÇÃO DE POTENCIAIS PRECURSORES DE NOVOS AGENTES ANTIMALÁRICOS
The aim of this study was develop in silico studies with a data set of 1 H -imidazol-2-yl-pyrimidine-4,6-diamines derivatives described as antimalarial agents with the intention of obtain data and tools useful in the development of new drugs of this class. A QSAR model was developed using topological, geometrical and electronic molecular descriptors with aid
Quím. Nova. Publicado em: 2016-06
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2. The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznid
Mem. Inst. Oswaldo Cruz. Publicado em: 25/04/2014
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3. Síntese, caracterização e polimerização de bis(metacrilamida)s
The aim of this study was the synthesis, characterization and investigation of kinetic behavior of photo- and thermal polymerization of 4,4-diphenylmethane-bis(methacrylamide) (BisFenil), N,N¿,hexamethylene-bis(methacrylamide) (BisHexa), N,N¿-decamethylene-bis(methacrylamide) (BisDeca) and N,N¿-dodecamethylene-bis(methacrylamide) (BisDodeca). Methacrylate
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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4. COMPLEXOS MONO E DINUCLEARES DE PLATINA(II) COM LIGANTES AMINADOS N-ALQUILADOS DE CADEIA LONGA: SÍNTESE, CARACTERIZAÇÃO E INCORPORAÇÃO EM LIPOSSOMAS
O câncer, atualmente, é considerado um problema de saúde pública, sendo responsável por cerca de 12% de todas as causas de óbito no mundo. O tratamento desta doença pode ser realizado através da quimioterapia, uma alternativa muito importante. Desde a descoberta da atividade antitumoral da cisplatina, a investigação a respeito do uso de complexos m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/12/2010
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5. Reações de enonas trialometilsubstituídas com aminas e diaminas: Síntese de análogos do etambutol / Reactions of trihalomethylsubstituted enones with amines and diamines. Synthesis of ethambutol analogues
Uma série de 5,5,5-trifluor-3-metil-(alquilmetilamino)-pentano-1,4-dióis, 5,5,5-trifluor-3-metil-(arilmetilamino)-pentano-1,4-dióis e N,N-bis[5,5,5-trifluor-3-metil-((alquilmetilamino]-pentano-1,4-dióis foram obtidos a partir da reação do 3- trifluoracetil-4,5-diidrofurano com aminas primárias e diaminas e subsequente reação de redução com borohid
Publicado em: 2010
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6. SÍNTESE E CARACTERIZAÇÃO DE COMPLEXOS DE PLATINA COM LIGANTES DIAMINADOS N-ALQUILADOS DE CADEIA LONGA CONTENDO UM GRUPO HIDROXILA
Cancer is considered one of the main causes of death around the world. This disease can be treated using radiotherapy, surgery, and chemotherapy. Since the discovery of the anticancer activity of cisplatin, studies involving the use of metal complexes as drugs have grown substantially. Aiming to improve the spectrum of antitumor activity, to decrease side ef
Publicado em: 2010
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7. Preparation and antitubercular activity of lipophilic diamines and amino alcohols
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-08
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8. Synthesis of new disulfonamides from different substituted diamino pyridines
A series of novel disulfonamide derivatives were synthesized and characterized by FT-IR, ¹H NMR and MS techniques. In order to prepare new disulfonamides, at first we synthesized new diamines containing a pyridine ring. Then, they have been reacted with sulfonyl chlorides to give corresponding disulfonamides.
Eclética Química. Publicado em: 2009
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9. New optically active and thermally stable poly(amide-imide)s containing N,N'-(Bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)-bis-L-alanine and aromatic diamines: synthesis and characterization
Cinco novas poliamidas-iminas (PAIs) oticamente ativas 6a-e foram preparadas pela reação de policondensação direta da N,N´-(biciclo[2,2,2]octa-7-eno-2,3,5,6-tetracarboxila)-bis-L-alanina 4 com várias diaminas aromáticas 5a-e usando solventes polares apróticos como a N-metil-2-pirrolidona (NMP). Neste procedimento, trifenil fosfito (TPP) e piridina fo
Journal of the Brazilian Chemical Society. Publicado em: 2009
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10. Purification of human IgG by negative chromatography on immobilized diamines in agarose gels / Purificação de IgG humana por cromatografia negativa em diaminas imobilizadas em geis de agarose
As imunoglobulinas (em particular, Imunoglobulina G (IgG)) têm uma aplicação ampla, sendo essenciais em testes de diagnóstico in vitro, em terapia, análises e investigação em diversas áreas. Muitos estudos têm sido realizados visando à purificação de IgG, destacando-se as técnicas de adsorção seletiva, como as cromatografias de troca iônica,
Publicado em: 2009
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11. AVALIAÇÃO DE NOVOS ANÁLOGOS DA TALIDOMIDA QUANTO A INIBIÇÃO DA PRODUÇÃO DE ÓXIDO NÍTRICO, CITOCINAS PRÓ-INFLAMATÓRIAS E EXPRESSÃO DE CD80 E CD86 EM MACRÓFAGOS
Thalidomide is used to treat various diseases including erythema nodosum leprosum (ENL), an inflammatory complication of leprosy. However, it has severe teratogenic activity and novel thalidomide analogues might be used to treat the disease without this severe side effect. A series of diamine compounds containing two hydrolyzed phthalimido structures were ch
Publicado em: 2009
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12. SÍNTESE, CARACTERIZAÇÃO E AVALIAÇÃO DA ATIVIDADE IMUNOSSUPRESSORA DE DIAMINAS E AMINOÁLCOOIS LIPOFÍLICOS
Immunosuppressant drugs are the main drugs that can affect the immune response, reducing the activation of the innate and acquired immunities. The immunosuppresive drugs are used in the treatment of several autoimmune diseases, some allergies, and in the prevention and/or treatment of the rejection of transplanted organs and tissues. The objective of the pre
Publicado em: 2008