Dissolution Kinetic
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity
Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica (SBA), Halloysite Nanotubes (HNTs) and Multiwalled Carbon Nanotubes (CNTs) were loaded with fluoroquinolone Levofloxacin (LVF) to be applied
Braz. J. Pharm. Sci.. Publicado em: 12/08/2019
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2. A study of the metallic silver dissolution with the MEA-NH3-Cu system
ABSTRACT Leaching of silver from minerals has been studied for decades. Recently, research has been focused on the substitution of cyanide (because of its high toxicity) from hydrometallurgical operations. In this sense, the development of alternative-green leaching solutions for the recovery of metallic silver from minerals and urban mines is necessary. In
Matéria (Rio J.). Publicado em: 19/07/2018
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3. First evaluation of semidirect recycling methods for the reclamation of cemented carbides based on a literature survey
ABSTRACT At the moment the industrially applied techniques for cemented carbide reclamation feature several deficiencies. Depending on the process route, obstacles consist in high energy and chemical consumption (indirect recycling methods) or a deterioration of the recycled product in comparison with the primary material (direct recycling approach). Therefo
Matéria (Rio J.). Publicado em: 19/07/2018
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4. Growth and Electrochemical Stability of Compact Tantalum Oxides Obtained in Different Electrolytes for Biomedical Applications
Tantalum has been cited to have many biomaterial applications, exhibiting biocompatibility and outstanding corrosion resistance. Tantalum may be covered with tantalum oxide using the electrochemical process of anodic oxidation. The oxide surface is known to be bioactive and more corrosion resistant. In this research, compact tantalum oxide films were obtaine
Mat. Res.. Publicado em: 23/10/2015
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5. Potentiometric Titration and Out-Of-Equilibrium pH Response of the Biotite‑Water System
Minerals in soils contribute significantly to the capacity of soils to buffer pH disturbance. In this paper, we present the pH buffering capacity of a common soil phyllosilicate mineral, biotite. We performed equilibrium potentiometric titrations and we also monitored the pH response kinetics of the mineral-water system in order to develop an out-of-equilibr
J. Braz. Chem. Soc.. Publicado em: 2015-09
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6. In vitro dissolution kinetic for mycophenolic acid derivatives tablets
Micofenolato de mofetila (MMF) e micofenolato sódico (MPS) são, respectivamente, éster e sal sódico do ácido micofenólico. Os fármacos possuem características farmacocinéticas distintas em função das diferenças na estrutura molecular, nas propriedades físico-químicas e nas formulações administradas. Neste trabalho, os perfis de dissolução d
Braz. J. Pharm. Sci.. Publicado em: 2013-06
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7. Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation
The aim of this work was to study the formulation and in vitro characterization of hydro dynamically balanced floating matrix tablets using Cefuroxime axetil (CA) as model drug. Different excipients such as hydroxy propyl methyl cellulose (HPMC) K15M, E5LV (gelling agent), sodium bicarbonate (gas generating agent) and sodium lauryl sulfate (SLS) (solubility
Brazilian Archives of Biology and Technology. Publicado em: 2012-04
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8. A fluorescence-based assay for octreotide in kinetic release from depot formulations
Here we report the validation of a derivatization method that makes use of fluorescamine as a selective reactant for the quantitative analysis of peptide and protein drugs in the dissolution profile from depot formulations. Typical current methods require separation of the nano/microparticles and time-consuming chromatographic runs. In this study we report a
Química Nova. Publicado em: 2012
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9. Effect of metal ions on the in vitro availability of enoxacin, its in vivo implications, kinetic and antibacterial studies
The present paper describes the effect of metals ions on the in vitro availability of enoxacin (a second generation quinolone antibiotic) owing to drug-metal interaction. These interaction studies were performed at 37 °C in different pH environments simulating human body compartments and were studied by UV spectroscopic technique. In order to determine the
Química Nova. Publicado em: 2011
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10. Olmesartana medoxomila : validação de metodologia analítica, avaliação biofarmacêutica e análise polimórfica / Olmesartan medoxomil: validation of analytical methodology, biopharmaceutical evaluation, and polymorphic analysis
O pró-fármaco olmesartana medoxomila (OLM) é um anti-hipertensivo representante da classe dos bloqueadores seletivos dos receptores da angiotensina II (BRA). No Brasil, encontra-se disponível sob a forma de comprimidos revestidos (Benicar®). Foi aprovado pelo FDA em 2002. Não existe monografia disponível para este fármaco em nenhum código oficial. D
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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11. Formulações de atrazina em xerogéis: síntese e caracterização
In this study, controlled release formulations of Atrazine (ATZ) were synthesized by the sol-gel method and characterized by elemental, FTIR, SEM, BET and DSC analyses. The release kinetic of ATZ from the formulations in CaCl2 0.01 mol L-1 medium was monitored by UV/Vis spectroscopy. In all formulations, ATZ was physically dispersed on the Si-polymer, and th
Química Nova. Publicado em: 2009
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12. Estudos de correlaÃÃo de parÃmetros tÃrmicos e de dissoluÃÃo do fluconazol na caracterizaÃÃo tecnolÃgica de desintegrantes
The real need to develop, to produce and to market drugs with high quality level, allied the diversity of products pharmaceutical resultant of different synthesis and purification processes, do one of the improvement of the control of quality of the raw materials of the great challenges of the pharmaceutical industries. The present work studies the correlati
Publicado em: 2008