Disulfide Bond
Mostrando 1-12 de 523 artigos, teses e dissertações.
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1. Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
In this study, we successfully demonstrated a strategy for specific disulfide bond formation by hybridization of two complementary peptide nucleic acid strands. Peptides were linked to the pair of complementary peptide nucleic acids by native chemical ligation, respectively, and base pairing drove the two peptides into close proximity for interchain disulfid
J. Braz. Chem. Soc.. Publicado em: 2020-05
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2. Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans
Abstract Background: Among the hymenopteran insect venoms, those from social wasps and bees - such as honeybee, hornets and paper wasps - have been well documented. Their venoms are composed of a number of peptides and proteins and used for defending their nests and themselves from predators. In contrast, the venoms of solitary wasps and bees have not been
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 28/09/2017
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3. Nova metodologia de diagnóstico para Ehrlichia canis: PCR X LAMP / New method of diagnostics for Ehrlichia canis: PCR x Lamp
Devido à estreita relação entre o homem e o cão, eventualmente alguns ectoparasitas de cães podem ser observados parasitando o homem. O carrapato Rhipicecephalus sanguineus é um ectoparasita que possui a capacidade de carregar e transmitir patógenos aos seres humanos. Esse artrópode, por exercer hematofagia, é o principal vetor biológico e reservat
Publicado em: 2010
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4. Estudos estruturais e funcionais das oxidoredutases de pontes dissulfeto da familia DsbA de Xylella fastidiosa / Structural and functional studies of the disulfide oxidorecdutases DsbA from Xylella fastidiosa
As oxidoredutases de pontes dissulfeto da família DsbA são responsáveis pela catálise da formação de pontes dissulfeto em proteínas secretadas para o periplasma, participando do processo de enovelamento de fatores de virulência de diversos organismos. É a proteína com maior potencial de oxidação atualmente caracterizada e tal propriedade é assoc
Publicado em: 2008
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5. Conseqüências da expressão da enzima Cu,Zn-superóxido dismutase (SOD1) e sua mutante G93A em neuroblastomas. Implicações para a esclerose lateral amiotrófica / Some consequences of SOD1 and G93A mutant expression in neuroblastomas. Implications for amyotrophic lateral sclerosis (ALS).
Cerca de 20 % dos casos familiares de esclerose lateral amiotrófica (ELAf) são causados por mutações na enzima Cu,Zn-superóxido dismutase (SOD1). Inicialmente se supôs que as enzimas mutantes teriam a atividade SOD comprometida, entretanto isto não foi comprovado. Atualmente, considera-se que as enzimas mutantes adquiram propriedades tóxicas. Quais s
Publicado em: 2007
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6. Secretion of Streptomyces tendae antifungal protein 1 by Lactococcus lactis
Lactococcus lactis, the model lactic acid bacterium, is a good candidate for heterologous protein production in both foodstuffs and the digestive tract. We attempted to produce Streptomyces tendae antifungal protein 1 (Afp1) in L. lactis with the objective of constructing a strain able to limit fungal growth. Since Afp1 activity requires disulfide bond (DSB)
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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7. Avaliação do desempenho de catalisadores do tipo Pt-Re-Sn/Al2O3 na reforma de n-octano.
Pt-Re-Sn/Al2O3-Cl catalysts were evaluated in the n-octane reforming to produce aromatics specially xylenes and were compared with the correspondent monometallic(Pt/Al2O3) and bimetallic (Pt-Re and Pt-Sn/Al2O3) ones. The samples were prepared by coimpregnation and successive impregnations of alumina, with the solutions of the metallic precursors. The solids
Publicado em: 2003
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8. Repression of photosynthesis gene expression by formation of a disulfide bond in CrtJ
Many species of purple photosynthetic bacteria repress synthesis of their photosystem in the presence of molecular oxygen. The bacterium Rhodobacter capsulatus mediates this process by repressing expression of bacteriochlorophyll, carotenoid, and light-harvesting genes via the aerobic repressor, CrtJ. In this study, we demonstrate that CrtJ forms an intramol
The National Academy of Sciences.
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9. An in vivo pathway for disulfide bond isomerization in Escherichia coli
Biochemical studies have shown that the periplasmic protein disulfide oxidoreductase DsbC can isomerize aberrant disulfide bonds. Here we present the first evidence for an in vivo role of DsbC in disulfide bond isomerization. Furthermore, our data suggest that the enzymes DsbA and DsbC play distinct roles in the cell in disulfide bond formation and isom
The National Academy of Sciences of the USA.
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10. The disulfide bond connecting the chains of ricin.
Studies on the disulfide bond connecting the two polypeptide chains of ricin are reported. Reduction of this bond in the native protein requires approximately 50-fold more mercaptoethanol than the reduction of the bond in the protein denatured by sodium dodecyl sulfate. An improved procedure for the formation of this disulfide bond from recombined chains is
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11. Structure and function in rhodopsin: Mass spectrometric identification of the abnormal intradiscal disulfide bond in misfolded retinitis pigmentosa mutants
Retinitis pigmentosa (RP) point mutations in both the intradiscal (ID) and transmembrane domains of rhodopsin cause partial or complete misfolding of rhodopsin, resulting in loss of 11-cis-retinal binding. Previous work has shown that misfolding is caused by the formation of a disulfide bond in the ID domain different from the native Cys-110–Cys-187 d
The National Academy of Sciences.
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12. A pathway for disulfide bond formation in vivo.
Protein disulfide bond formation in Escherichia coli requires the periplasmic protein DsbA. We describe here mutations in the gene for a second protein, DsbB, which is also necessary for disulfide bond formation. Evidence suggests that DsbB may act by reoxidizing DsbA, thereby regenerating its ability to donate its disulfide bond to target proteins. We propo