Drug Compression
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. Mass Variation Rate, in Acidic Environment, of Polyhydroxybutyrate and Chitosan matrices with Potential Application as Controlled Drug Delivery System
Polymers such as the biocompatible polyhydroxybutyrate (PHB) and the polysaccharide chitosan (Chi), a pH-sensitive polymer, have been studied for drug delivery applications and scaffolds production. In this work, matrices of PHB and Chi were produced by compression molding (SPHB-Chi) and loaded with a broad-spectrum biocide chlorhexidine (CHX) (SPHB-Chi-CHX)
Mat. Res.. Publicado em: 30/09/2019
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2. Development of fast dissolving tablets of flurbiprofen by sublimation method and its in vitro evaluation
Flurbiprofen belongs to Biopharmaceutical Classification System (BCS) class II drugs which are poorly soluble in water. The objective of present research work was to prepare fast dissolving tablets of Flurbiprofen using varying concentrations of three different sublimating agents to improve the dissolution rate. Seven formulations were prepared containing di
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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3. The development and characterization of Propranolol Tablets using Tapioca starch as excipient
Abstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to
An. Acad. Bras. Ciênc.. Publicado em: 08/04/2019
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4. Preparation and in vitro & in vivo evaluation of cephalexin matrix tablets
The purpose of the study is to develop cephalexin controlled-release matrix tablets by using lower proportions of release retardant polymer and to establish their in vitro & in vivo correlation. Tablets were compressed by incorporating polymers in a matrix form along with drug which prolong the drug release. Twelve formulations were prepared by mixing ethyl
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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5. Application of statistical process control for spotting compliance to good pharmaceutical practice
ABSTRACT For the release of pharmaceutical products into the drug market; most of the pharmaceutical companies depend on acceptance criteria - that are set internally, regulatory and/or pharmacopeially. However, statistical process control monitoring is underestimated in most quality control in cases; although it is important not only for process stability a
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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6. Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline
Abstract The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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7. Physical characterization of multiparticulate systems
ABSTRACT The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the ran
Braz. J. Pharm. Sci.. Publicado em: 07/05/2018
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8. Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion
ABSTRACT Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then oral
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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9. In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug
ABSTRACT A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethyl cellulose (EC) were prepared using direct compression and
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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10. Preparation and characterization of solid oral dosage forms containing soy isoflavones
Soy isoflavones have been extensively used for menopausal symptoms and prevention of hormone-related cancer, osteoporosis and cardiovascular diseases. Commercially available forms of isoflavones include supplements, capsules and tablets. However, the non-standardization of soy isoflavones extracts and different dissolution profiles of these solid dosage form
Rev. bras. farmacogn.. Publicado em: 01/02/2013
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11. Controle de qualidade e avaliação das propriedades tecnológicas das formas polimórficas de talidomida / Quality control and evaluation of technological properties of polymorphic forms of thalidomide
Thalidomide was widely prescribed between 1950 and 1960, in nearly 50 countries, as sedative and antiemetic for morning sickness during pregnancy. After the occurrence of serious problems of teratogenicity it was heavily controlled. Growing interest has been observed in recent years to identify and elucidate the anti-inflammatory, immunomodulatory and anti-a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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12. Study of pre-formulation, pharmaceutical development and characterization of solid dosage forms of olanzapine / Estudo de pré-formulação, desenvolvimento farmacotécnico e caracterização de formas farmacêuticas sólidas da olanzapina
Among manufacturing processes available, direct compression is indicated for OLZ because this drug is moisture sensitive. Before drug developement, preformulation investigations involving physical and chemical properties of drug and excipient combined and separated must be performed. Thus, drug solubility profile, thermal analysis techniques, mainly DSC and
Publicado em: 2010