Drug Resistance Viral
Mostrando 1-12 de 285 artigos, teses e dissertações.
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1. HCMV UL97 phosphotransferase gene mutations may be associated with antiviral resistance in immunocompromised patients in Belém, PA, Northern Brazil
Abstract INTRODUCTION: Human cytomegalovirus is one of the causes of opportunist infections in immunocompromised patients, and is triggered by factors such as state of viral latency, weakened immune responses, and development of antiviral resistance to ganciclovir, the only drug offered by the public health system in Brazil to treat the infection. The goal
Rev. Soc. Bras. Med. Trop.. Publicado em: 2018-04
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2. Virological suppression in children and adolescents is not influenced by genotyping, but depends on optimal adherence to antiretroviral therapy
ABSTRACT Objective: To evaluate the virological outcomes in children and adolescents infected with HIV-1 in Salvador, Bahia according to genotyping results. Methods: We retrospectively evaluated the rates of virological suppression of children and adolescents submitted to HIV-1 genotyping test from January/2008 to December/2012. The participants were follo
Braz J Infect Dis. Publicado em: 2017-06
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3. Extensive variation in drug-resistance mutational profile of Brazilian patients failing antiretroviral therapy in five large Brazilian cities
Abstract Background Development of drug-resistance mutations is the main cause of failure in antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients failing antiretroviral therapy. Objectives To define the HIV mutational profile associated with drug resistance in Brazilian patients from 5 large cities, after first,
Braz J Infect Dis. Publicado em: 2016-08
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4. Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors
Reverse transcriptase (RT) is a multifunctional enzyme in the human immunodeficiency virus (HIV)-1 life cycle and represents a primary target for drug discovery efforts against HIV-1 infection. Two classes of RT inhibitors, the nucleoside RT inhibitors (NRTIs) and the nonnucleoside transcriptase inhibitors are prominently used in the highly active antiretrov
Mem. Inst. Oswaldo Cruz. Publicado em: 2015-11
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5. Transmitted human immunodeficiency virus-1 drug resistance in a cohort of men who have sex with men in Belo Horizonte, Brazil - 1996-2012
The presence of transmitted human immunodeficiency virus (HIV)-1 drug-resistance (TDR) at the time of antiretroviral therapy initiation is associated with failure to achieve viral load (VL) suppression. Here, we report TDR surveillance in a specific population of men who have sex with men (MSM) in Belo Horizonte, Brazil. In this study, the rate of TDR was ev
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-06
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6. Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months. However, the current treatment is only effective in 50% of patients infected with HCV genotype 1, the most prevalent genotype in Brazil.
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
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7. Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco
Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndro
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-06
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8. Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
The effectiveness of antiviral treatments of chronic hepatitis B has been poorly studied in Brazil. Here, hepatitis B virus (HBV) DNA positivity, drug resistance mutations and their association with HBV genotypes were evaluated in chronically HBV-infected patients under different drug regimens in Brazil. The study involved 129 patients under interferon or nu
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-05
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9. HIV-1 tropism and CD4 T lymphocyte recovery in a prospective cohort of patients initiating HAART in Ribeirão Preto, Brazil
While human immunodeficiency virus (HIV)-1 chemokine co-receptors 5 tropism and the GWGR motif in the envelope third variable region (V3 loop) have been associated with a slower disease progression, their influence on antiretroviral response remains unclear. The impact of baseline V3 characteristics on treatment response was evaluated in a randomised, double
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-02
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10. Resistência Primária aos Antirretrovirais e Mapeamento Genético do HIV-1 no Estado do Mato Grosso / Primary Antiretroviral Resistance and High HIV-1 Genetic Diversity in Patients from Mato Grosso State, Central West Brazil
O uso de antirretrovirais (ARVs) reduziu a morbi-mortalidade relacionada à infecção pelo vírus da imunodeficiência humana (HIV). Apesar deste avanço, as mutações de resistência aos antirretrovirais e a diversidade genética do HIV-1 permanecem os principais obstáculos na luta contra a AIDS. O padrão de resistência do HIV-1 aos ARVs pode ser deter
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/03/2011
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11. HIV-1 drug resistance genotypic profiles in children with undetectable plasma viremia during antiretroviral therapy
Treatment of HIV-1 infection with highly active antiretroviral therapy has led to sustained viral suppression in the plasma in a large number of children. However, studies have suggested that the integrated provirus in resting CD4+ T lymphocytes could be a source of reactivatable virus and maintain drug-resistant virus. We evaluated the resistance-related mu
Brazilian Journal of Infectious Diseases. Publicado em: 2011-02
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12. HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil
Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated th
Brazilian Journal of Infectious Diseases. Publicado em: 2010-08