Endothelin Receptor
Mostrando 1-12 de 138 artigos, teses e dissertações.
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1. Pulmonary Hypertension in General Cardiology Practice
Resumo O achado de hipertensão pulmonar (HP) em avaliação ecocardiográfica é frequente e preocupante. No entanto, o ecocardiograma é apenas um exame sugestivo e não diagnóstico de HP. Quando se suspeita de acometimento direto da circulação pulmonar, está indicada medida hemodinâmica invasiva para estabelecer o diagnóstico. Essa avaliação permi
Arq. Bras. Cardiol.. Publicado em: 10/10/2019
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2. Antioxidant effect of endothelin-1 receptor antagonist protects the rat kidney against chronic injury induced by hypertension and hyperglycemia
RESUMO Hipertensão e Diabetes Mellitus figuram como as duas principais causas de doença renal crônica que culmina em doença renal terminal. Uma vez que os dois fatores de risco são comuns e podem se sobrepor, novas abordagens preventivas e terapêuticas se fazem necessárias. O macitentan (MAC) é um novo antagonista não-seletivo dos receptores da endo
J. Bras. Nefrol.. Publicado em: 02/09/2019
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3. Expression profile of endothelin receptors (ETA and ETB) and microRNAs-155 and -199 in the corpus cavernosum of rats submitted to chronic alcoholism and diabetes mellitus
Recent evidence shows that chronic ethanol consumption increases endothelin (ET)-1 induced sustained contraction of trabecular smooth muscle cells of the corpora cavernosa in corpus cavernosum of rats by a mechanism that involves increased expression of ETA and ETB receptors. Our goal was to evaluate the effects of alcohol and diabetes and their relationship
Braz J Med Biol Res. Publicado em: 01/03/2018
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4. Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats
Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to evaluate the effect of Endothelin-1 (ET-1) receptor blockad
Braz J Med Biol Res. Publicado em: 11/12/2017
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5. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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6. Participação da endotelina-1 na sinovite induzida por carragenina na articulação temporomandibular de ratos. / Endothelin-1 participation on the rats temporomandibular joint synovitis induced by carrageenan.
Disfunções temporomandibulares são secundárias à inflamação e dor. Estudos mostram a participação da ET na nocicepção. Investigamos o papel da ET1 na sinovite induzida pela injeção de CGN na ATM de ratos. Injeções intra-articulares de CGN, ET1 ou do agonista do receptor ETB BQ3020 foram realizadas na ATM. Após 4h, a hiperalgesia foi avaliada
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/05/2012
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7. Caracterização da disfunção erétil em camundongos obesos tratados com dieta hiperlipídica / Characterization of erectile dysfunction in obese mice fed a high-fat diet
The prevalence of obesity is increasing every year, and a becoming a major public health problem. Obesity is considered an important risk factor for development of insulin resistance, dyslipidemia, diabetes mellitus type 2 and arterial hypertension. These are risk factors that act synergistically in the development of erectile dysfunction. However, so far fe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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8. CPU0213, a novel endothelin type A and type B receptor antagonist, protects against myocardial ischemia/reperfusion injury in rats
The efficacy of endothelin receptor antagonists in protecting against myocardial ischemia/reperfusion (I/R) injury is controversial, and the mechanisms remain unclear. The aim of this study was to investigate the effects of CPU0123, a novel endothelin type A and type B receptor antagonist, on myocardial I/R injury and to explore the mechanisms involved. Male
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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9. Schistosomiasis differentially affects vasoconstrictor responses: up-regulation of 5-HT receptor-mediated aorta contraction
Schistosomiasis, classified by the World Health Organization as a neglected tropical disease, is an intravascular parasitic disease associated to a chronic inflammatory state. Evidence implicating inflammation in vascular dysfunction continues to mount, which, broadly defined, reflects a failure in the control of intracellular Ca2+ and consequently, vascular
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-06
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10. Efeito da endotelina sobre a expressão gênica das melanopsinas (Opn4x e Opn4m) e do receptor de endotelina, subtipo ETc, em melanóforo de Xenopus laevis / Effect of endothelin on the gene expression of melanopsins (Opn4x and Opn4m) and endothelin receptor subtype ETc in melanophores of Xenopus laevis
The biological clocks are critical for synchronizing the behavior of organisms to changes in photoperiod. All rhythmic changes are crucial to the survival of the species since they provide for internal adjustments to coincide with the phase of the cycle most favorable. Many of these biological rhythms are clearly associated with the light-dark cycle, of majo
Publicado em: 2010
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11. Estudo das alterações da resposta vasodilatadora e vasoconstritora em aortas de ratas diabéticas e os mecanismos envolvidos. / Study of the alterations of the vasodilator and the vasoconstrictor responses in aortas of the diabetic female rats and the mechanisms involved.
Thirty days after induction of diabetes, in aortas with endothelium (E+) of diabetic female rats (DB), the maximum response (Rmax) to potassium chloride (KCl) was reduced and the Rmax to noradrenaline (NE) was similar to controls (CT). The endothelium (E-) removal increased the response to KCl and NE, but this increase was of a lower magnitude in DB than in
Publicado em: 2009
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12. Efeitos renais e vasculares do extrato bruto da anÃmona marinha Bunodosoma caissarum e sua fraÃÃo fosfolipase a2: estudo dos mediadores envolvidos / Bunodosoma caissarum and it\ s phospholipase A2 fraction effects in the isolated perfusion kidney and arteriolar mesenteric bed
AnÃmonas marinhas contÃm uma variedade de compostos biologicamente ativos incluindo potentes toxinas. Por esta razÃo, muitos investigadores tÃm centrado seus estudos nestas proteÃnas, isoladas de anÃmonas marinhas, como Bunodosoma caissarum. O objetivo deste trabalho foi estudar o mecanismo das alteraÃÃes funcionais produzidas pelo extrato bruto e da
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/01/2008