Enediynes
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Teluretos vinÃlicos: reaÃÃes de acoplamento e investigaÃÃo da regio- e estereoquÃmica da hidroteluraÃÃo de alquinos
Vinylic tellurides are valuable synthetic intermediates and have recently been used in the total synthesis of many natural products. The hydrotelluration of alkynes is usually the method of choice to prepare Z-vinylic tellurides, in view of the easy access to the starting materials, the high regio- and stereoselectivity of the reaction and the practicality o
Publicado em: 2006
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2. Vinylic tellurides as precursors in a stereoselective and convergent route to Z-enynes and Z-trisubstituted enediynes
Teluretos vinílicos Z são transformados em cianocupratos vinílicos Z de ordem superior por transmetalação com dimetil- ou com n-butil(tienil)cianocupratos de lítio. Reação dos cianocupratos vinílicos Z assim obtidos com cloreto de zinco fornece presumivelmente espécies mistas de zinco e cobre que reagem com bromoalquinos levando a eninos e enediino
Journal of the Brazilian Chemical Society. Publicado em: 2004-06
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3. Cell-specific regulation of apoptosis by designed enediynes.
The naturally occurring enediyne antibiotics are a unique class of antitumor drugs that combine reactive enediynes with additional structural features conferring affinity for DNA. Dynemicin A, in which an enediyne core is attached to an anthraquinone group capable of DNA intercalation, readily cleaves double-stranded DNA. This activity is thought to be the b
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4. A continuous assay for DNA cleavage: The application of “break lights” to enediynes, iron-dependent agents, and nucleases
Although extensive effort has been applied toward understanding the mechanism by which enediynes cleave DNA, a continuous assay for this phenomenon is still lacking. In fact, with the exception of assays for DNase, continuous assays for most DNA cleavage events are unavailable. This article describes the application of “molecular break lights” (a si
The National Academy of Sciences.
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5. Chemistry and biology of natural and designed enediynes.
Ever since the initial reports of the enediyne anticancer antibiotics in the late 1980s, researchers from a number of disciplines have been devoting increasing attention to their chemistry, biology, and potential medical applications. Synthetic chemists and molecular designers have been engaged in attempts to synthesize these molecules and to model their uni
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6. Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab
Prodrugs of dynemicin analogs were synthesized, and their activation by aldolase antibody (Ab) 38C2 was evaluated by DNA-cleaving activity, as well as tumor cell growth inhibition. Further, we provide evidence that the activated enediynes underwent covalent crosscoupling with the aldolase Ab, which appears to be a limiting factor of their tumor cell growth-i
National Academy of Sciences.
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7. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model
A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of this methodology to clone remaining prototypical genes from producers of structurally determined enediynes in both family types are presented. A phylogenetic analysis of the new pool of bona fide enediyne PKS genes, consisting of thre
National Academy of Sciences.
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8. Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.
Kedarcidin chromophore is a 9-membered enediyne, recently isolated from an actinomycete strain. In vivo studies show this molecule to be extremely active against P388 leukemia and B16 melanoma. Cytotoxicity assays on the HCT116 colon carcinoma cell line result in an IC50 value of 1 nM. In vitro experiments with phi X174, pM2 DNA, and 32P-end-labeled restrict