Enzimatic Inhibitors
Mostrando 1-2 de 2 artigos, teses e dissertações.
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1. Atividade enzimática da ADAMTS-13 e padrão de fragmentação do fator de von Willebrand em crianças hipoxêmicas portadoras de cardiopatias congênitas / ADAMTS-13 enzimatic activity and von Willebrand factor subunit proteolysis in children with cyanotic congenital heart disease
Hypoxia has been shown to alter several biochemical mechanisms in endothelial cells. In addition, hypoxia induces the endothelial expression of adhesion molecules, including von Willebrand factor (VWF). Increased release of high-molecular-weight VWF multimers is associated with higher risk for thrombotic events. In physiological conditions, the multimeric pa
Publicado em: 2010
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2. Modelagem quântica de inibidores enzimáticos. / Quantum modelling of enzimatic inhibitors.
We have made a structural and electronic characterization of the enzyme inhibitors E-64 and CA030 using quantum chemistry techniques. Geometry optimizations are performed in the ab initio level with the Hartree-Fock and Density Functional Theory methods and these structures are then compared with crystallographic results obtained from the Protein Data Bank.
Publicado em: 2002