Eukaryotic Cells
Mostrando 1-12 de 2440 artigos, teses e dissertações.
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1. In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis
Abstract Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation of targets by cleavage or degradation of the mRNA. Fungi of the Paracoccidioides complex are the etiological agents of the main systemic mycosis of Latin America. These fungi present a plasticity to adapt and survive in
Genet. Mol. Biol.. Publicado em: 14/02/2019
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2. BONEFILL ® block as alternative for bone substitute: a toxicological evaluation
ABSTRACT Bone substitutes based on hydroxyapatite (HA) and Bonefill® (BO - inorganic bovine bone) associated with poly(lactic-co-glycolic acid) (PLGA) (HA/PLGA and BO/PLGA) were evaluated concerning cytotoxicity, genotoxicity and mutagenicity as potential candidates for bone repair. The materials were developed and provided by Bionnovation Biomedical Produc
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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3. Analysis of radioprotection and antimutagenic effects of Ilex paraguariensis infusion and its component rutin
DNA repair pathways, cell cycle checkpoints, and redox protection systems are essential factors for securing genomic stability. The aim of the present study was to analyze the effect of Ilex paraguariensis (Ip) infusion and one of its polyphenolic components rutin on cellular and molecular damage induced by ionizing radiation. Ip is a beverage drank by most
Braz J Med Biol Res. Publicado em: 16/07/2018
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4. COMO ESTUDAR INTERAÇÕES ENTRE NANOPARTÍCULAS E SISTEMAS BIOLÓGICOS
Although in recent years there has been an increasing amount of literature on nanotechnology and their clinical applications, it is still scarce a deep understanding of the interactions at the molecular levels between nanoparticles and cells. Studies demonstrating the underlying mechanisms of nanoparticles endocytosis, intracellular trafficking, and cellular
Quím. Nova. Publicado em: 2016-12
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5. Membrane permeabilization of colistin toward pan-drug resistant Gram-negative isolates
Abstract Pan-drug resistant Gram-negative bacteria, being resistant to most available antibiotics, represent a huge threat to the medical community. Colistin is considered the last therapeutic option for patients in hospital settings. Thus, we were concerned in this study to demonstrate the membrane permeabilizing activity of colistin focusing on investigati
Braz. J. Microbiol.. Publicado em: 2016-06
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6. B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization
In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells. Previous research has shown that the intramuscular immunization of BALB/c mice with a naked plasmid DNA fragment encoding the Mycobacterium leprae 65-kDa heat-shock protein (pcDNA3-Hsp65) induces prote
Braz J Med Biol Res. Publicado em: 18/09/2015
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7. Invasin
gimB found in a bovine intestinalEscherichia coli with an adherent and invasive profileThe invasin
gimB (genetic island associated with human newborn meningitis) is usually found in ExPEC (Extraintestinal PathogenicEscherichia coli ) such as UPEC (uropathogenicE. coli ), NMEC (neonatal meningitisE. coli ) and APEC (avian pathogenicE. coli ). In NMEC,Braz. J. Microbiol.. Publicado em: 2015-09
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8. PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway
PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations of PCI-24781 (0, 0.25, 0.5, 1, 2.5 and 5 M) and analyze
Genet. Mol. Biol.. Publicado em: 21/10/2014
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9. Brazilian propolis protects Saccharomyces cerevisiae cells against oxidative stress
Propolis is a natural product widely used for humans. Due to its complex composition, a number of applications (antimicrobial, antiinflammatory, anesthetic, cytostatic and antioxidant) have been attributed to this substance. Using Saccharomyces cerevisiae as a eukaryotic model we investigated the mechanisms underlying the antioxidant effect of propolis from
Braz. J. Microbiol.. Publicado em: 17/12/2013
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10. Morphology and 18S rDNA gene sequence of Spirostomum minus and Spirostomum teres (Ciliophora: Heterotrichea) from Rio de Janeiro, Brazil
Species of Spirostomum Ehrenberg, 1838 are widely used as model organisms in ecological studies of environmental impacts and symbioses between ciliates and human pathogenic bacteria. However, the taxonomy of this genus is confused by the superficiality of the morphological descriptions of its included species, and the use of only a few characters for their d
Zoologia (Curitiba). Publicado em: 2013-02
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11. Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chro
Genet. Mol. Biol.. Publicado em: 2013
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12. Gene transfer of Chlorella vulgaris n-3 fatty acid desaturase optimizes the fatty acid composition of human breast cancer cells
Chlorella vulgaris has the gene of n-3 fatty acid desaturase (CvFad3), which can synthesize the precursor of n-3 polyunsaturated fatty acids (PUFAs) or convert n-6 to n-3 PUFAs. The objective of the present study was to examine whether the CvFad3 gene from C. vulgaris can be functionally and efficiently expressed in human breast cancer cells and whether its
Braz J Med Biol Res. Publicado em: 2012-12