Extended Release
Mostrando 1-12 de 174 artigos, teses e dissertações.
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1. Efficient Encapsulation and Controlled Release of N,N-Diethyl-3-methylbenzamide (DEET) from Oil-in-Water Emulsions Stabilized by Cationic Nanocellulose and Silica Nanoparticles
Oil-in-water emulsions containing N,N-diethyl-3-methylbenzamide (DEET) were developed aiming to extend the sustained release of the active compound, by using two oppositely charged nanomaterials, namely silica nanoparticles (SiNP) and cationic cellulose nanofibrils (CCNF), as stabilizers, and a mixture of food-grade nonionic surfactants to avoid precipitatio
Journal of the Brazilian Chemical Society. Publicado em: 2023
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2. HYDROXYAPATITE - CARBON NANOTUBE COMPOSITES FOR DRUG DELIVERY APPLICATIONS
Abstract The aim of this study was the synthesis of composites containing hydroxyapatite (Hap) or silicon substituted hydroxyapatite (HapSi), carboxyl functionalized carbon nanotubes (fMWCNT) and gelatin (G) in different ratios. Ibuprofen (IBU) was chosen as a model drug for the formulation of extended-release dosage forms. The obtained composites were chara
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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3. Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times fol
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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4. ECONOMIC PERFORMANCE OF LOBLOLLY PINE STANDS IN SOUTHERN BRAZIL AS A RESULT OF DIFFERENT CROWN THINNING INTENSITIES1
RESUMO Aproximadamente 1,6 milhões de hectares são cultivados com Pinus no sul do Brasil, principalmente com Pinus taeda L. Mais de um terço dos povoamentos pertencem a produtores de toras independentes, cujos objetivos são maximizar os resultados econômicos. Neste estudo, um experimento de desbastes foi avaliado durante um período de produção de 30
Rev. Árvore. Publicado em: 13/06/2019
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5. Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem
Abstract Objective This study aimed to analyze the following physicochemical properties: radiopacity, final setting time, calcium release, pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability of two calcium silicate-based materials. Material and methods We tested MTA Repair HP and MTA Vitalcem in comparison with
J. Appl. Oral Sci.. Publicado em: 05/04/2018
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6. The effect of extended release tolterodine used for overactive bladder treatment on female sexual function
ABSTRACT Introduction Overactive bladder (OAB) is a common condition, especially in middle aged women, requiring long term therapy with anticholinergics to maintain symptoms relief. The aim of the study was to determine the effect of tolterodine extended release (ER) used for OAB treatment on the sexual function of women. Materials and Methods Between Au
Int. braz j urol.. Publicado em: 2017-08
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7. Ameliorating the antitumor activity of lenalidomide using PLGA nanoparticles for the treatment of multiple myeloma
Abstract Lenalidomide (LND) is an anti-cancer drug and an effective derivative of thalidomide used for multiple myeloma therapy. Because of its poor solubility in water, LND is known to cause low oral bioavailability (below 33%), and as a direct consequence of this, the dosing frequency is extended thus increasing risk of toxicity. To improve its bioavailabi
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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8. In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug
ABSTRACT A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethyl cellulose (EC) were prepared using direct compression and
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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9. Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease
ABSTRACT The present research work was envisaged to develop bilayer tablets to improve therapeutic efficacy of antibiotic combination for the treatment of sexually transmitted diseases. The combination of two antibiotics i.e. cefixime trihydrate and ofloxacin were used for the preparation of bilayer tablets which act against genito-urinary infections. The fo
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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10. INCORPORATION AND RELEASE KINETICS OF ALPHA-BISABOLOL FROM PCL AND CHITOSAN/GUAR GUM MEMBRANES
Abstract Alpha-bisabolol, an anti-inflammatory and antioxidant compound extracted from candeia trees (Eremanthus erythropappus), was incorporated into hydrophobic polycaprolactone (PCL) and hydrophilic chitosan/guar gum (Ch-G) membranes aiming at the production of bioactive wound dressings. The incorporation efficiency achieved a maximum of ca. 18% (1 gram o
Braz. J. Chem. Eng.. Publicado em: 2016-09
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11. Obtenção e caracterização de matriz apropriada para sistemas de liberação prolongada: estudos de liberação dos herbicidas atrazina e diuron
This study aimed to produce and characterize a novel material from fish scales and chitosan for use as a medium for the extended release of herbicides. The mechanism of release for the herbicides atrazine and diuron was influenced by diffusion and swelling according to the power law kinetic model. The atrazine release time was seven days, while that of diuro
Quím. Nova. Publicado em: 2014-06
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12. Preparation and scale up of extended-release tablets of bromopride
A reprodutibilidade do processo de fabricação de comprimidos e o controle das suas propriedades farmacotécnicas depende da otimização dos aspectos de formulação e dos parâmetros de processo. O planejamento de experimentos como o Desenho de Experimentos (DOE) pode ser utilizado para acelerar a produção desta formulação, em particular, para a obten
Braz. J. Pharm. Sci.. Publicado em: 2014-04